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Dietary factors, homocystein, MTHFR gene polymorphisms, and cardiovascular risk in adults and the elderly: a population-based study - ISA - Capital

Grant number: 09/15831-0
Support type:Regular Research Grants
Duration: January 01, 2010 - December 31, 2011
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Principal researcher:Regina Mara Fisberg
Grantee:Regina Mara Fisberg
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

In recent years clinical and epidemiological studies have evidenced plasma levels of homocystein are associated to increased risk of atherosclerosis and ischemic cardiovascular events. Among adults, blood homocystein shows specific characteristics and distribution according to age and gender. But, there are scarce Brazilian studies investigating this subject in representative samples of general population. The objective of the present study is to assess the association between cardiovascular risk factors and blood levels of homocystein, MTHFR gene polymorphisms and dietary factors in a probabilistic sample of subjects included in the second phase of ISA study, a population-based household health survey in the city of São Paulo. Demographic, socioeconomic and lifestyle information including diet, physical activity, smoking and alcohol abuse will be collected as well as data on blood pressure, anthropometric measures, and venous blood samples. Food intake information will be collected at two different opportunities using a 24-hour food recall (24HR). Cholesterol and its fractions, homocystein, folate, vitamin B12 and B16 and biomarkers of inflammatory response involved in atherosclerosis etiology will be measured in the blood drawn. DNA will be extracted and amplified by PCR using specific primers for two MTHFR polymorphisms (A1298C and C677T). The product will undergo digestion using Hinf I enzyme (New England BioLabs) for C677T and Mbo II (New England BioLabs) for A128C. All digestion products will be assayed in 3% agarose gel, and ethidium bromide stained. The associations of interest will be analyzed using non-conditional logistic regression or linear regression. (AU)

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Scientific publications (41)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE MELLO, ALINE VERONEZE; SARTI, FLAVIA MORI; FISBERG, REGINA MARA. How to Estimate Food Prices and Diet Costs in Population-Based Studies?. FRONTIERS IN NUTRITION, v. 8, OCT 22 2021. Web of Science Citations: 0.
FONTANELLI, MARIANE DE M.; SALES, CRISTIANE H.; DE CASTRO, MICHELLE A.; FISBERG, REGINA M. Healthful grain foods consumption by Sao Paulo residents: a 12-year analysis and future trends. PUBLIC HEALTH NUTRITION, v. 24, n. 10, p. 2987-2997, JUL 2021. Web of Science Citations: 0.
FERREIRA CARIOCA, ANTONIO AUGUSTO; STELUTI, JOSIANE; DE CARVALHO, ALINE MARTINS; SILVA, ALEXSANDRO MACEDO; GUERREIRO DA SILVA, ISMAEL DALE COTRIM; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Plasma metabolomics are associated with metabolic syndrome: A targeted approach. NUTRITION, v. 83, MAR 2021. Web of Science Citations: 0.
BATISTA, LAIS DUARTE; DE FRANCA, NATASHA APARECIDA GRANDE; PFRIMER, KARINA; FONTANELLI, MARIANE DE MELLO; FERRIOLLI, EDUARDO; FISBERG, REGINA MARA. Estimating total daily energy requirements in community-dwelling older adults: validity of previous predictive equations and modeling of a new approach. European Journal of Clinical Nutrition, v. 75, n. 1, p. 133-140, JAN 2021. Web of Science Citations: 0.
DE MENESES FUJII, TATIANE MIEKO; NORDE, MARINA MAINTINGUER; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA; ORDOVAS, JOSE M.; ROGERO, MARCELO MACEDO. FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women. Nutrition Research, v. 78, p. 42-49, JUN 2020. Web of Science Citations: 0.
FERREIRA CARIOCA, ANTONIO AUGUSTO; GORGULHO, BARTIRA; FONTANELLI, MARIANE DE MELLO; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Cardiometabolic risk profile and diet quality among internal migrants in Brazil: a population-based study. EUROPEAN JOURNAL OF NUTRITION, v. 60, n. 2 MAY 2020. Web of Science Citations: 2.
NORDE, MARINA M.; FISBERG, REGINA M.; MARCHIONI, DIRCE M. L.; ROGERO, MARCELO MACEDO. Systemic low-grade inflammation-associated lifestyle, diet, and genetic factors: A population-based cross-sectional study. NUTRITION, v. 70, FEB 2020. Web of Science Citations: 0.
AMANDA SILVA FONTES; ANA CAROLINA PALLOTTINI; DIVA ALIETE DOS SANTOS VIEIRA; MARIANE DE MELLO FONTANELLI; DIRCE MARIA MARCHIONI; CHESTER LUIZ GALVÃO CESAR; MARIA CECILIA GOI PORTO ALVES; MOISÉS GOLDBAUM; REGINA MARA FISBERG. Demographic, socioeconomic and lifestyle factors associated with sugar-sweetened beverage intake: a population-based study. Revista Brasileira de Epidemiologia, v. 23, p. -, 2020.
PEREIRA, JAQUELINE LOPES; DOS SANTOS VIEIRA, DIVA ALIETE; GOI PORTO ALVES, MARIA CECILIA; GALVAO CESAR, CHESTER LUIS; GOLDBAUM, MOISES; FISBERG, REGINA MARA. Excess body weight in the city of SAo Paulo: panorama from 2003 to 2015, associated factors and projection for the next years. BMC PUBLIC HEALTH, v. 18, DEC 3 2018. Web of Science Citations: 1.
DE MELLO, ALINE VERONEZE; SARTI, FLAVIA MORI; PEREIRA, JAQUELINE LOPES; GOLDBAUM, MOISES; GALVAO CESAR, CHESTER LUIZ; GOI PORTO ALVES, MARIA CECILIA; FISBERG, REGINA MARA. Determinants of inequalities in the quality of Brazilian diet: trends in 12-year population-based study (2003-2015). INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH, v. 17, JUN 7 2018. Web of Science Citations: 1.
PEREIRA, JAQUELINE LOPES; FELIX, PAULA VICTORIA; MATTEI, JOSIEMER; FISBERG, REGINA MARA. Differences over 12 Years in Food Portion Size and Association with Excess Body Weight in the City of SAo Paulo, Brazil. NUTRIENTS, v. 10, n. 6 JUN 2018. Web of Science Citations: 0.
FONTANELLI, MARIANE DE MELLO; SALES, CRISTIANE HERMES; FERREIRA CARIOCA, ANTONIO AUGUSTO; MARCHIONI, DIRCE MARIA; FISBERG, REGINA MARA. The relationship between carbohydrate quality and the prevalence of metabolic syndrome: challenges of glycemic index and glycemic load. EUROPEAN JOURNAL OF NUTRITION, v. 57, n. 3, p. 1197-1205, APR 2018. Web of Science Citations: 5.
NORDE, MARINA MAINTINGUER; OKI, ERICA; FERREIRA CARIOCA, ANTONIO AUGUSTO; TEIXEIRA DAMASCENO, NAGILA RAQUEL; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA; ROGERO, MARCELO MACEDO. Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study. Clinical Nutrition, v. 37, n. 2, p. 659-666, APR 2018. Web of Science Citations: 5.
FERREIRA CARIOCA, ANTONIO AUGUSTO; GORGULHO, BARTIRA; TEIXEIRA, JULIANA ARAUJO; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Dietary patterns in internal migrants in a continental country: A population-based study. PLoS One, v. 12, n. 10 OCT 16 2017. Web of Science Citations: 1.
SANTOS, ROBERTA DE OLIVEIRA; DOS SANTOS VIEIRA, DIVA ALIETE; MACHADO MIRANDA, ANDREIA ALEXANDRA; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA; BALTAR, VALERIA TRONCOSO. The traditional lunch pattern is inversely correlated with body mass index in a population-based study in Brazil. BMC PUBLIC HEALTH, v. 18, JUL 19 2017. Web of Science Citations: 9.
OKI, ERICA; NORDE, MARINA N.; CARIOCA, ANTONIO A. F.; SOUZA, JOSE M. P.; CASTRO, INAR A.; MARCHIONI, DIRCE M. L.; FISBERG, REGINA M.; ROGERO, MARCELO M. Polymorphisms of the TNF-alpha gene interact with plasma fatty acids on inflammatory biomarker profile: a population-based, cross-sectional study in Sao Paulo, Brazil. BRITISH JOURNAL OF NUTRITION, v. 117, n. 12, p. 1663-1673, JUN 2017. Web of Science Citations: 4.
PALLOTTINI, ANA CAROLINA; SALES, CRISTIANE HERMES; DOS SANTOS VIEIRA, DIVA ALIETE; MARCHIONI, DIRCE MARIA; FISBERG, REGINA MARA. Dietary BCAA Intake Is Associated with Demographic, Socioeconomic and Lifestyle Factors in Residents of Sao Paulo, Brazil. NUTRIENTS, v. 9, n. 5 MAY 2017. Web of Science Citations: 4.
DE CARVALHO, ALINE MARTINS; FALCAO DE OLIVEIRA, ANTONIO ANAX; DE MELO LOUREIRO, ANA PAULA; FIGARO GATTAS, GILKA JORGE; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Arginine intake is associated with oxidative stress in a general population. NUTRITION, v. 33, p. 211-215, JAN 2017. Web of Science Citations: 3.
SALES, CRISTIANE H.; FONTANELLI, MARIANE DE M.; VIEIRA, DIVA A. S.; MARCHIONI, DIRCE M.; FISBERG, REGINA M. Inadequate dietary intake of minerals: prevalence and association with socio-demographic and lifestyle factors. BRITISH JOURNAL OF NUTRITION, v. 117, n. 2, p. 267-277, JAN 2017. Web of Science Citations: 3.
MIRANDA, ANDREIA MACHADO; STELUTI, JOSIANE; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Association between Polyphenol Intake and Hypertension in Adults and Older Adults: A Population-Based Study in Brazil. PLoS One, v. 11, n. 10 OCT 28 2016. Web of Science Citations: 23.
PEREIRA, JAQUELINE LOPES; MENDES, ALINE; CRISPIM, SANDRA PATRICIA; MARCHIONI, DIRCE MARIA; FISBERG, REGINA MARA. Association of Overweight with Food Portion Size among Adults of Sao Paulo - Brazil. PLoS One, v. 11, n. 10 OCT 5 2016. Web of Science Citations: 4.
CASTRO, MICHELLE ALESSANDRA; BALTAR, VALERIA TRONCOSO; MARCHIONI, DIRCE MARIA; FISBERG, REGINA MARA. Examining associations between dietary patterns and metabolic CVD risk factors: a novel use of structural equation modelling. BRITISH JOURNAL OF NUTRITION, v. 115, n. 9, p. 1586-1597, MAY 14 2016. Web of Science Citations: 6.
FELIX DOS SANTOS, PAULA VICTORIA; SALES, CRISTIANE HERMES; SANTOS VIEIRA, DIVA ALIETE; FONTANELLI, MARIANE DE MELLO; MARCHIONI, DIRCE MARIA; FISBERG, REGINA MARA. Family income per capita, age, and smoking status are predictors of low fiber intake in residents of Sao Paulo, Brazil. Nutrition Research, v. 36, n. 5, p. 478-487, MAY 2016. Web of Science Citations: 3.
MIRANDA, A. M.; STELUTI, J.; FISBERG, R. M.; MARCHIONI, D. M. Dietary intake and food contributors of polyphenols in adults and elderly adults of Sao Paulo: a population-based. BRITISH JOURNAL OF NUTRITION, v. 115, n. 6, p. 1061-1070, MAR 28 2016. Web of Science Citations: 16.
MENDES, ALINE; PEREIRA, JAQUELINE LOPES; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA. Dietary energy density was associated with diet quality in Brazilian adults and older adults. APPETITE, v. 97, p. 120-126, FEB 1 2016. Web of Science Citations: 2.
DE CARVALHO, ALINE MARTINS; FERREIRA CARIOCA, ANTONIO AUGUSTO; FISBERG, REGINA MARA; QI, LU; MARCHIONI, DIRCE MARIA. Joint association of fruit, vegetable, and heterocyclic amine intake with DNA damage levels in a general population. NUTRITION, v. 32, n. 2, p. 260-264, FEB 2016. Web of Science Citations: 4.
NORDE, MARINA MAINTINGUER; OKI, ERICA; DE CASTRO, INAR ALVES; PACHECO SOUZA, JOSE MARIA; TEIXEIRA DAMASCENO, NAGILA RAQUEL; MARA FISBERG, REGINA; LOBO MARCHIONI, DIRCE MARIA; ROGERO, MARCELO MACEDO. Influence of adiponectin gene variants and plasma fatty acids on systemic inflammation state association-A cross-sectional population-based study, SAo Paulo, Brazil. MOLECULAR NUTRITION & FOOD RESEARCH, v. 60, n. 2, p. 278-286, FEB 2016. Web of Science Citations: 1.
OKI, ERICA; NORDE, MARINA M.; CARIOCA, ANTONIO A. F.; IKEDA, RENATA E.; SOUZA, JOSE M. P.; CASTRO, INAR A.; MARCHIONI, DIRCE M. L.; FISBERG, REGINA M.; ROGERO, MARCELO M. Interaction of SNP in the CRP gene and plasma fatty acid profile in inflammatory pattern: A cross-sectional population-based study. NUTRITION, v. 32, n. 1, p. 88-94, JAN 2016. Web of Science Citations: 10.
SANTOS, ROBERTA DE OLIVEIRA; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA; BALTAR, VALERIA TRONCOSO. Dietary patterns for meals of Brazilian adults. BRITISH JOURNAL OF NUTRITION, v. 114, n. 5, p. 822-828, SEP 14 2015. Web of Science Citations: 25.
POSSA, GABRIELA; DE CASTRO, MICHELLE ALESSANDRA; LOBO MARCHIONI, DIRCE MARIA; FISBERG, REGINA MARA; FISBERG, MAURO. Probability and amounts of yogurt intake are differently affected by sociodemographic, economic, and lifestyle factors in adults and the elderly-results from a population-based study. Nutrition Research, v. 35, n. 8, p. 700-706, AUG 2015. Web of Science Citations: 6.
RODRIGUES-MOTTA, MARIANA; GALVIS SOTO, DIANA MILENA; LACHOS, VICTOR H.; VILCA, FILIDOR; BALTAR, VALERIA TRONCOSO; VERLY JUNIOR, ELISEU; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA. A mixed-effect model for positive responses augmented by zeros. STATISTICS IN MEDICINE, v. 34, n. 10, p. 1761-1778, MAY 10 2015. Web of Science Citations: 3.
CARVALHO, A. M.; MIRANDA, A. M.; SANTOS, F. A.; LOUREIRO, A. P. M.; FISBERG, R. M.; MARCHIONI, D. M. High intake of heterocyclic amines from meat is associated with oxidative stress. BRITISH JOURNAL OF NUTRITION, v. 113, n. 8, p. 1301-1307, APR 28 2015. Web of Science Citations: 13.
DE CASTRO, MICHELLE ALESSANDRA; BALTAR, VALERIA TRONCOSO; LOBO MARCHIONI, DIRCE MARIA; FISBERG, REGINA MARA. Sex differences in serum leptin and its relation to markers of cardiometabolic risk in middle-aged adults: Evidence from a population-based study. NUTRITION, v. 31, n. 3, p. 491-497, MAR 2015. Web of Science Citations: 6.
VERLY-, JR., ELISEU; STELUTI, JOSIANE; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA LOBO. A Quantile Regression Approach Can Reveal the Effect of Fruit and Vegetable Consumption on Plasma Homocysteine Levels. PLoS One, v. 9, n. 11 NOV 3 2014. Web of Science Citations: 13.
DE CASTRO SELEM, SORAYA SANT'ANA; DE CASTRO, MICHELLE ALESSANDRA; GALVAO CESAR, CHESTER LUIZ; LOBO MARCHIONI, DIRCE MARIA; FISBERG, REGINA MARA. Associations between Dietary Patterns and Self-Reported Hypertension among Brazilian Adults: A Cross-Sectional Population-Based Study. JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS, v. 114, n. 8, p. 1216-1222, AUG 2014. Web of Science Citations: 17.
DE CARVALHO, ALINE MARTINS; GALVAO CESAR, CHESTER LUIZ; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Meat Consumption in Sao Paulo - Brazil: Trend in the Last Decade. PLoS One, v. 9, n. 5 MAY 2 2014. Web of Science Citations: 18.
GABRIELA FERREIRA AVELINO; ÁGATHA NOGUEIRA PREVIDELLI; MICHELLE ALESSANDRA DE CASTRO; DIRCE MARIA LOBO MARCHIONI; REGINA MARA FISBERG. Sub-relato da ingestão energética e fatores associados em estudo de base populacional. Cadernos de Saúde Pública, v. 30, n. 3, p. 663-668, Mar. 2014.
KAROLINE HONORATO BRUNACIO; ELISEU VERLY-JR; CHESTER LUIZ GALVÃO CESAR; REGINA MARA FISBERG; DIRCE MARIA MARCHIONI. Uso de suplementos dietéticos entre residentes do Município de São Paulo, Brasil. Cadernos de Saúde Pública, v. 29, n. 7, p. 1467-1472, Jul. 2013.
MARTINI, LIGIA A.; VERLY, JR., ELISEU; MARCHIONI, DIRCE M. L.; FISBERG, REGINA M. Prevalence and correlates of calcium and vitamin D status adequacy in adolescents, adults, and elderly from the Health Survey-Sao Paulo. NUTRITION, v. 29, n. 6, p. 845-850, JUN 2013. Web of Science Citations: 35.
ELISEU VERLY JUNIOR; ALINE MARTINS DE CARVALHO; REGINA MARA FISBERG; DIRCE MARIA LOBO MARCHIONI. Adesão ao guia alimentar para população brasileira. Revista de Saúde Pública, v. 47, n. 6, p. -, Dez. 2013.
VERLY-JR, E.; FISBERG, R. M.; MARCHIONI, D. M. L. Is the food frequency consumption essential as covariate to estimate usual intake of episodically consumed foods?. European Journal of Clinical Nutrition, v. 66, n. 11, p. 1254-1258, NOV 2012. Web of Science Citations: 2.

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