Evidence about the relationship between folate one carbon metabolism pathway and three important outcomes in health: low birth weight, persistent HPV infection in men and risk factors for cardiovascular diseases

• Grant number: 14/12647-1
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): March 01, 2015
• Effective date (End): June 30, 2018
• Field of knowledge: Health Sciences - Nutrition - Nutritional Analysis of Population
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Dirce Maria Lobo Marchioni
• Grantee: Juliana Araujo Teixeira
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 16/15356-3 - Folic acid supplementation and the developmental origins of health and disease: a comparison between birth cohort studies in Brazil and New Zealand, BE.EP.DR

Abstract

The folate one carbon metabolism pathway is important to health maintenance and your imbalance is associated with pregnancy complications, cardiovascular and neurodegenerative diseases, bone fracture and cancer. This study aim to explore the relationship between folate one carbon metabolism pathway and three important outcomes in health: low birth weight, persistent HPV infection in men and risk factors for cardiovascular diseases. Will be used secondary data of PROCRIAR Study, a cohort of pregnant women followed up until the birth of their children, which will be explored the association between dietary intake of folate, vitamins B6 and B12 of the mother and low birth weight of her child. The HIM Study (HPV Infection in Men) who also is a cohort study with follow-up for 4 years of Brazilian men assessed every six months, including data from HPV infection in the penis, anus and oral mucosa. The association between dietary intake of folate, vitamins B6 and B12 and persistence of HPV infection in men will be investigated. The relation between folate, vitamins B6 and B12, homocysteine, hypertension and other risk factors for cardiovascular diseases will be explored taking into account interactions of polymorphisms of MTHFR and polyunsaturated fatty acids in the ISA-Capital Study. The last study has cross-sectional design, population-based. The three studies used food frequency questionnaire and/or 24 Hours Recall to measure dietary intake. Additionally, in the ISA-Capital Study blood biochemical parameters of folate, vitamins B6 and B12, homocysteine, polyunsaturated fatty acids and polymorphisms of MTHFR was measured. Demographic, socioeconomic, anthropometric and lifestyle variables, morbidity, family history of diseases, use of supplements and medications will be considered in the data analysis. All data were collected. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA CARIOCA, ANTONIO AUGUSTO; GORGULHO, BARTIRA; TEIXEIRA, JULIANA ARAUJO; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Dietary patterns in internal migrants in a continental country: A population-based study. PLoS One, v. 12, n. 10, OCT 16 2017. (14/19355-6, 14/12647-1, 09/15831-0, 14/16347-2)

TEIXEIRA, JULIANA A.; HOFFMAN, DANIEL J.; CASTRO, TERESA G.; SALDIVA, SILVIA REGINA D. M.; FRANCISCO, V, ROSSANA P.; VIEIRA, SANDRA ELISABETE; MARCHIONI, DIRCE MARIA. Pre-pregnancy dietary pattern is associated with newborn size: results from ProcriAr study. BRITISH JOURNAL OF NUTRITION, v. 126, n. 6, p. 903-912, SEP 28 2021. (09/17315-9, 14/12647-1)

TEIXEIRA, JULIANA ARAUJO; CASTRO, TERESA GONTIJO; GRANT, CAMERON C.; WALL, CLARE R.; DA SILVA CASTRO, ANA LUCIA; VIEIRA FRANCISCO, ROSSANA PULCINELI; VIEIRA, SANDRA ELISABETE; DIAS MEDICI SALDIVA, SILVIA REGINA; MARCHIONI, DIRCE MARIA. Dietary patterns are influenced by socio-demographic conditions of women in childbearing age: a cohort study of pregnant women. BMC PUBLIC HEALTH, v. 18, MAR 1 2018. (08/57717-6, 14/12647-1, 09/17315-9)

TEIXEIRA, JULIANA ARAUJO; STELUTI, JOSIANE; GORGULHO, BARTIRA MENDES; FERREIRA CARIOCA, ANTONIO AUGUSTO; ALENCAR, GIZELTON PEREIRA; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Prudent dietary pattern influences homocysteine level more than folate, vitamin B12, and docosahexaenoic acid: a structural equation model approach. EUROPEAN JOURNAL OF NUTRITION, v. 59, n. 1, p. 81-91, FEB 2020. (14/12647-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

TEIXEIRA, Juliana Araujo. Dietary patterns, nutrients involved in one-carbon metabolism and three health outcomes. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) São Paulo.