FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women

Author(s)

de Meneses Fujii, Tatiane Mieko ^[1] ; Norde, Marina Maintinguer ^[1] ; Fisberg, Regina Mara ^[1] ; Lobo Marchioni, Dirce Maria ^[1] ; Ordovas, Jose M. ^{[2, 3]} ; Rogero, Marcelo Macedo ^{[1, 4]}

Affiliation

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil

^[2] Tufts Univ, JM USDA HNRCA, 711 Washington St, Boston, MA 02111 - USA

^[3] IMDEA Alimentac, Madrid - Spain

^[4] Sao Paulo Res Fdn, Food Res Ctr FoRC, Res Innovat & Disseminat Ctr, CEPID FAPESP, BR-05468140 Sao Paulo - Brazil

• Document type: Journal article
• Source: Nutrition Research; v. 78, p. 42-49, JUN 2020.
• Web of Science Citations: 0

Abstract

Cardiometabolic risk involves environmental and genetic factors. We aimed to investigate the relationship between plasma fatty acids and single nucleotide polymorphisms (SNPs), located in elongase and desaturases genes, and cardiometabolic parameters in a cross-sectional population-based survey. A sample of 226 adults who participated in the Health Survey of Sao Paulo, Brazil, was selected. Clinical and anthropometric variables, plasma lipoprotein, and fatty acid were evaluated. We hypothesized that differences in SNPs could lead to changes in plasma long-chain polyunsaturated fatty acids. We analyzed the relationship between SNPs in FADS1 (rs174546) and ELOVL2 (rs953413) genes, plasma fatty acid profiles, and cardiometabolic-related phenotypes using multiple linear regression, which was adjusted for confounders. Plasma high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels were significantly lower in carriers of the T allele for the FADS1 SNP. Plasma oleic acid levels were statistically higher in individuals with CT/TT genotypes in the FADS1 and AG/CC genotypes in the ELOVL2 SNPs in comparison to the CC and AA genotypes, respectively. Higher levels of linoleic and linolenic acid were found for Tallele carriers of FADS1 SNP. The estimated activity of the stearoyl CoA desaturase enzyme (SDC\_18) was higher in the CT/TT genotypes (FADS1). Delta-5 desaturase estimated activity was statistically lower in the presence of the minor FADS1 allele. The estimated activity of the enzyme delta-6 desaturase was statistically lower for FADS1 CT and TT genotypes. SNPs in FADS1 and ELOVL2 genes showed protective associations for lipid metabolism and could be markers of lower cardiometabolic risk. (C) 2020 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 12/20401-7 - Association between SNP related to adiponectin, C-reactive protein, Toll Like Receptor 4, TNF-alfa, IL-1 beta, IL-6 and IL-10 genes and lipids intake and their effects on plasma inflammatory biomarkers levels in population-based study
• Grantee: Marcelo Macedo Rogero
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/05125-7 - Lifestyle, biochemical and genetic markers as cardiometabolic risk factors: Health Survey in São Paulo City
• Grantee: Regina Mara Fisberg
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 09/15831-0 - Dietary factors, homocystein, MTHFR gene polymorphisms, and cardiovascular risk in adults and the elderly: a population-based study - ISA - Capital
• Grantee: Regina Mara Fisberg
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/22113-9 - Biochemical indicators of micronutrient status and usual intakes of residents from the City of São Paulo - ISA-Capital Survey 2013
• Grantee: Regina Mara Fisberg
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/03803-5 - Association of dietary patterns and single nucleotide plymorphisms in the genes of adiponectin, Toll like receptor-4, IL-1², IL-6, IL-10, TNF-±, CCL-2 and C reactive protein with a systemic inflammatory pattern at a population-based study - ISA-Capital
• Grantee: Marina Maintinguer Norde
• Support Opportunities: Scholarships in Brazil - Doctorate