FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women

Autor(es)

de Meneses Fujii, Tatiane Mieko ^[1] ; Norde, Marina Maintinguer ^[1] ; Fisberg, Regina Mara ^[1] ; Lobo Marchioni, Dirce Maria ^[1] ; Ordovas, Jose M. ^{[2, 3]} ; Rogero, Marcelo Macedo ^{[1, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil

^[2] Tufts Univ, JM USDA HNRCA, 711 Washington St, Boston, MA 02111 - USA

^[3] IMDEA Alimentac, Madrid - Spain

^[4] Sao Paulo Res Fdn, Food Res Ctr FoRC, Res Innovat & Disseminat Ctr, CEPID FAPESP, BR-05468140 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Nutrition Research; v. 78, p. 42-49, JUN 2020.
• Citações Web of Science: 0

Resumo

Cardiometabolic risk involves environmental and genetic factors. We aimed to investigate the relationship between plasma fatty acids and single nucleotide polymorphisms (SNPs), located in elongase and desaturases genes, and cardiometabolic parameters in a cross-sectional population-based survey. A sample of 226 adults who participated in the Health Survey of Sao Paulo, Brazil, was selected. Clinical and anthropometric variables, plasma lipoprotein, and fatty acid were evaluated. We hypothesized that differences in SNPs could lead to changes in plasma long-chain polyunsaturated fatty acids. We analyzed the relationship between SNPs in FADS1 (rs174546) and ELOVL2 (rs953413) genes, plasma fatty acid profiles, and cardiometabolic-related phenotypes using multiple linear regression, which was adjusted for confounders. Plasma high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels were significantly lower in carriers of the T allele for the FADS1 SNP. Plasma oleic acid levels were statistically higher in individuals with CT/TT genotypes in the FADS1 and AG/CC genotypes in the ELOVL2 SNPs in comparison to the CC and AA genotypes, respectively. Higher levels of linoleic and linolenic acid were found for Tallele carriers of FADS1 SNP. The estimated activity of the stearoyl CoA desaturase enzyme (SDC\_18) was higher in the CT/TT genotypes (FADS1). Delta-5 desaturase estimated activity was statistically lower in the presence of the minor FADS1 allele. The estimated activity of the enzyme delta-6 desaturase was statistically lower for FADS1 CT and TT genotypes. SNPs in FADS1 and ELOVL2 genes showed protective associations for lipid metabolism and could be markers of lower cardiometabolic risk. (C) 2020 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 12/20401-7 - Associação entre SNP relacionados aos genes da adiponectina, proteína C reativa, TLR4, TNF-alfa, IL-1 beta, IL-6 e IL-10 e ingestão de lipídios e seus efeitos sobre a concentração plasmática de biomarcadores inflamatórios em estudo de base populacional
• Beneficiário: Marcelo Macedo Rogero
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/05125-7 - Estilo de vida, marcadores bioquímicos e genéticos como fatores de risco cardiometabólico: inquérito de saúde na cidade de São Paulo
• Beneficiário: Regina Mara Fisberg
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 07/51488-2 - Métodos para estimativa da prevalência de inadequação de nutrientes em indivíduos residentes no município de São Paulo
• Beneficiário: Regina Mara Fisberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/15831-0 - Fatores dietéticos, homocisteína, polimorfismos do gene MTHFR e risco cardiovascular em adultos e idosos: estudo de base populacional - ISA - capital
• Beneficiário: Regina Mara Fisberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/22113-9 - Indicadores bioquímicos do estado nutricional de micronutrientes e consumo alimentar habitual de residentes do Município de São Paulo - Estudo ISA 2013
• Beneficiário: Regina Mara Fisberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/03803-5 - Associação de padrões alimentares e de polimorfismos de nucleotídeo único dos genes da adiponectina, receptor do tipo Toll 4, IL-1², IL-6, IL-10, TNF-±, CCL-2 e proteína C reativa com um padrão inflamatório sistêmico em um estudo de base populacional- ISA
• Beneficiário: Marina Maintinguer Norde
• Modalidade de apoio: Bolsas no Brasil - Doutorado