Influence of adiponectin gene variants and plasma fatty acids on systemic inflammation state association-A cross-sectional population-based study, SAo Paulo, Brazil

Author(s)

Norde, Marina Maintinguer ^[1] ; Oki, Erica ^[1] ; de Castro, Inar Alves ^[2] ; Pacheco Souza, Jose Maria ^[3] ; Teixeira Damasceno, Nagila Raquel ^[1] ; Mara Fisberg, Regina ^[1] ; Lobo Marchioni, Dirce Maria ^[1] ; Rogero, Marcelo Macedo ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-05508 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, BR-05508 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, BR-05508 Sao Paulo - Brazil

• Document type: Journal article
• Source: MOLECULAR NUTRITION & FOOD RESEARCH; v. 60, n. 2, p. 278-286, FEB 2016.
• Web of Science Citations: 1

Abstract

ScopeInteractions between adiponectin genetic variants and plasma fatty acid profile can modulate plasma inflammatory biomarker concentration and the risk for metabolic diseases. The aim of this study was to investigate the interaction between single nucleotide polymorphisms of the adiponectin gene and plasma fatty acid profile in modulating the odds for systemic inflammation in a cross-sectional population-based study. Methods and resultsInflammatory patterns comprised 11 inflammatory biomarkers. Among participants of the Health Survey of SAo Paulo, 262 adults (19-59 years) met the inclusion criteria. Anthropometric parameters, blood pressure, plasma inflammatory biomarker concentration, and fatty acid profile were measured and five single nucleotide polymorphisms of the adiponectin gene (rs2241766, rs1501299, rs16861209, rs17300539, and rs266729) genotyped. Individuals in the upper 50th percentile for plasma araquidonic acid, n-3 highly unsaturated fatty acid and estimated delta-5-desaturase activity, had reduced odds of being in the inflammatory cluster (OR (95% CI) = 0.55 (0.32-0.95), 0.50 (0.28-0.88) and 0.48 (0.28-0.83), respectively). Gene-plasma fatty acid profile interaction was found between rs2241766 and n-3 (p = 0.019), rs16861209 and araquidonic acid and docosapentaenoic acid (p = 0.044, p = 0.037, respectively), and rs17300539 and saturated fatty acid (p = 0.019). ConclusionPlasma fatty acid profile can interact with adiponectin gene variants to modulate the risk for systemic inflammatory state. (AU)

• FAPESP's process: 12/20401-7 - Association between SNP related to adiponectin, C-reactive protein, Toll Like Receptor 4, TNF-alfa, IL-1 beta, IL-6 and IL-10 genes and lipids intake and their effects on plasma inflammatory biomarkers levels in population-based study
• Grantee: Marcelo Macedo Rogero
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/01740-8 - Association between single nucleotide polymorphism related to adiponectin, Toll like receptor 4, IL-1² and IL-6 genes and fatty acids intake and their effects on systemic inflammatory pattern in a population based study - ISA capital.
• Grantee: Marina Maintinguer Norde
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 09/15831-0 - Dietary factors, homocystein, MTHFR gene polymorphisms, and cardiovascular risk in adults and the elderly: a population-based study - ISA - Capital
• Grantee: Regina Mara Fisberg
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/01741-4 - Association between single nucleotide polymorphism in genes of CRP, TNF-alfa and IL-10 and plasma fatty acids and their effect to a systemic inflammatory patter at a population-based study - ISA-Capital
• Grantee: Érica Oki
• Support Opportunities: Scholarships in Brazil - Master