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Epidemiological study of coffee consumption, its contribution for polyphenols intake and potential effects on cardiovascular risk factors, considering individual genetic variations

Grant number: 14/04540-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2014
Effective date (End): November 30, 2017
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Dirce Maria Lobo Marchioni
Grantee:Andreia Alexandra Machado Miranda
Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Coffee is the most consumed beverage in Brazil and the Western world, which explains the great interest among researchers. Among the various substances in the chemical composition of coffee, in addition to the nutrients, stand out caffeine and polyphenols. Some studies have verified the physiological effects of these bioactive substances on human health, particularly in chronic diseases such as cardiovascular disease. However, the results are conflicting and inconclusive. The objectives of this study are estimate the prevalence of coffee consumption and its contribution in polyphenol intake in our population and investigate the association of coffee with cardiovascular risk factors. This project will use data derived from two cross-sectional population based studies: Family Budget Survey (FBS) conducted in 2008 and 2009 and Health Survey-Sao Paulo (HS-Sao Paulo) conducted in 2008 and 2009. Will be used FBS data to estimate the prevalence of coffee consumption and polyphenols. To evaluate potential associations of coffee intake with cardiovascular risk factors, data from HS-Sao Paulo will be used. The study sample includes 26,390 adults and elderly people who participated in the National Survey of Feed in POF. It also covers 548 participants residing in Sao Paulo, from the investigation HS-Sao Paulo. The individual food consumption was estimated by the Food Record in FBS and three dietary surveys (two 24 hour Recalls and a Food Frequency Questionnaire) on the HS-Sao Paulo. The HS-Sao Paulo study, will be used indicator variables of cardiovascular risk factors (blood pressure and homocysteine), biomarkers, anthropometric measures, demographic, socioeconomic and lifestyle data and checked polymorphisms involved in the metabolism of caffeine and coffee consumption. The polymorphisms genotyping will be performed using the specific technique PCR-allele. Statistical analysis will be performed by multiple regression models in STATA ®, considered the significance level of 5 %. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MIRANDA, A. M.; STELUTI, J.; FISBERG, R. M.; MARCHIONI, D. M.. Dietary intake and food contributors of polyphenols in adults and elderly adults of Sao Paulo: a population-based. BRITISH JOURNAL OF NUTRITION, v. 115, n. 6, p. 1061-1070, . (14/04540-2, 09/15831-0)
MIRANDA, ANDREIA MACHADO; FERREIRA CARIOCA, ANTONIO AUGUSTO; STELUTI, JOSIANE; COTRIM GUERREIRO DA SILVA, ISMAEL DALE; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. The effect of coffee intake on lysophosphatidylcholines: A targeted metabolomic approach. Clinical Nutrition, v. 36, n. 6, p. 1635-1641, . (14/04540-2)
MIRANDA, ANDREIA MACHADO; STELUTI, JOSIANE; NORDE, MARINA MAINTINGUER; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. The association between genetic risk score and blood pressure is modified by coffee consumption: Gene-diet interaction analysis in a population-based study. Clinical Nutrition, v. 38, n. 4, p. 1721-1728, . (14/04540-2)
MIRANDA, ANDREIA MACHADO; STELUTI, JOSIANE; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Association between Polyphenol Intake and Hypertension in Adults and Older Adults: A Population-Based Study in Brazil. PLoS One, v. 11, n. 10, . (14/04540-2, 09/15831-0)
DE CARVALHO, ALINE MARTINS; CASTRO SELEM, SORAYA SANT'ANA DE; MIRANDA, ANDREIA MACHADO; MARCHIONI, DIRCE MARIA. Excessive red and processed meat intake: relations with health and environment in Brazil. BRITISH JOURNAL OF NUTRITION, v. 115, n. 11, p. 2011-2016, . (14/04607-0, 14/04540-2)
MIRANDA, ANDREIA M.; STELUTI, JOSIANE; GOULART, ALESSANDRA C.; BENSENOR, ISABELA M.; LOTUFO, PAULO A.; MARCHIONI, DIRCE M.. Coffee Consumption and Coronary Artery Calcium Score: Cross-Sectional Results of ELSA-Brasil (Brazilian Longitudinal Study of Adult Health). JOURNAL OF THE AMERICAN HEART ASSOCIATION, v. 7, n. 7, . (14/04540-2, 11/12256-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MIRANDA, Andreia Alexandra Machado. Epidemiological study of coffee consumption, its contribution to the intake of polyphenols and their potential effects in cardiovascular risk factors, considering individual genetic variations. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) São Paulo.

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