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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Arginine intake is associated with oxidative stress in a general population

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Author(s):
de Carvalho, Aline Martins ; Falcao de Oliveira, Antonio Anax ; de Melo Loureiro, Ana Paula ; Figaro Gattas, Gilka Jorge ; Fisberg, Regina Mara ; Marchioni, Dirce Maria
Total Authors: 6
Document type: Journal article
Source: NUTRITION; v. 33, p. 211-215, JAN 2017.
Web of Science Citations: 3
Abstract

Objective: The aim of this study was to assess the association between protein and arginine from meat intake and oxidative stress in a general population. Methods: Data came from the Health Survey for Sao Paulo (ISA-Capital), a cross-sectional population based study in Brazil (N = 549 adults). Food intake was estimated by a 24-h dietary recall. Oxidative stress was estimated by malondialdehyde (MDA) concentration in plasma. Analyses were performed using general linear regression models adjusted for some genetic, lifestyle, and biochemical confounders. Results: MDA levels were associated with meat intake (P for linear trend = 0.031), protein from meat (P for linear trend = 0.006), and arginine from meat (P for linear trend = 0.044) after adjustments for confounders: age, sex, body mass index, smoking, physical activity, intake of fruit and vegetables, energy and heterocyclic amines, C-reactive protein levels, and polymorphisms in GSTM1 (glutathione S-transferase Mu 1) and GSTT1 (glutathione S-transferase theta 1) genes. Results were not significant for total protein and protein from vegetable intake (P > 0.05). Conclusions: High protein and arginine from meat intake were associated with oxidative stress independently of genetic, lifestyle, and biochemical confounders in a population-based study. Our results suggested a novel link between high protein/arginine intake and oxidative stress, which is a major cause of age -related diseases. (C) 2016 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/08617-4 - Variables on glycemic control and pathogenesis of diabetic nephropathy: research on the phenomenon of metabolic memory
Grantee:Antonio Anáx Falcão de Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/04607-0 - Relationship between meat and heterocyclic amines intake and biochemical and genetic biomarkers
Grantee:Aline Martins de Carvalho
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 12/10965-0 - Meat and heterocyclic amines intake, relationship with biomarkers for exposure and susceptibility to cancer in ISA-Capital study
Grantee:Aline Martins de Carvalho
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 09/15831-0 - Dietary factors, homocystein, MTHFR gene polymorphisms, and cardiovascular risk in adults and the elderly: a population-based study - ISA - Capital
Grantee:Regina Mara Fisberg
Support Opportunities: Regular Research Grants