Arginine intake is associated with oxidative stress in a general population

Author(s)

de Carvalho, Aline Martins ; Falcao de Oliveira, Antonio Anax ; de Melo Loureiro, Ana Paula ; Figaro Gattas, Gilka Jorge ; Fisberg, Regina Mara ; Marchioni, Dirce Maria

• Document type: Journal article
• Source: NUTRITION; v. 33, p. 211-215, JAN 2017.
• Web of Science Citations: 3

Abstract

Objective: The aim of this study was to assess the association between protein and arginine from meat intake and oxidative stress in a general population. Methods: Data came from the Health Survey for Sao Paulo (ISA-Capital), a cross-sectional population based study in Brazil (N = 549 adults). Food intake was estimated by a 24-h dietary recall. Oxidative stress was estimated by malondialdehyde (MDA) concentration in plasma. Analyses were performed using general linear regression models adjusted for some genetic, lifestyle, and biochemical confounders. Results: MDA levels were associated with meat intake (P for linear trend = 0.031), protein from meat (P for linear trend = 0.006), and arginine from meat (P for linear trend = 0.044) after adjustments for confounders: age, sex, body mass index, smoking, physical activity, intake of fruit and vegetables, energy and heterocyclic amines, C-reactive protein levels, and polymorphisms in GSTM1 (glutathione S-transferase Mu 1) and GSTT1 (glutathione S-transferase theta 1) genes. Results were not significant for total protein and protein from vegetable intake (P > 0.05). Conclusions: High protein and arginine from meat intake were associated with oxidative stress independently of genetic, lifestyle, and biochemical confounders in a population-based study. Our results suggested a novel link between high protein/arginine intake and oxidative stress, which is a major cause of age -related diseases. (C) 2016 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 12/08617-4 - Variables on glycemic control and pathogenesis of diabetic nephropathy: research on the phenomenon of metabolic memory
• Grantee: Antonio Anáx Falcão de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 14/04607-0 - Relationship between meat and heterocyclic amines intake and biochemical and genetic biomarkers
• Grantee: Aline Martins de Carvalho
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 12/10965-0 - Meat and heterocyclic amines intake, relationship with biomarkers for exposure and susceptibility to cancer in ISA-Capital study
• Grantee: Aline Martins de Carvalho
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 09/15831-0 - Dietary factors, homocystein, MTHFR gene polymorphisms, and cardiovascular risk in adults and the elderly: a population-based study - ISA - Capital
• Grantee: Regina Mara Fisberg
• Support Opportunities: Regular Research Grants