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Meat and heterocyclic amines intake, relationship with biomarkers for exposure and susceptibility to cancer in ISA-Capital study

Grant number: 12/10965-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2012
Effective date (End): January 31, 2016
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Principal researcher:Dirce Maria Lobo Marchioni
Grantee:Aline Martins de Carvalho
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):14/04607-0 - Relationship between meat and heterocyclic amines intake and biochemical and genetic biomarkers, BE.EP.DR


High meat intake has been related with high risk to cancer. One of answer to meat has been related with cancer is the cooking methods that it is prepared, which it forms heterocyclic amines. These amines can form toxic substances during their metabolism, that is related with oxidative stress and DNA damage. However, people can present different answers to same dietetic exposition, they can present different risks or benefits with the same food intake. The study objective is evaluate the relationship between meat and heterocyclic amines intake with biomarkers for exposure to cancer (DNA adducts and malondialdehyde), considering the susceptibility biomarkers (enzymes polymorphisms) and social, demographics and life style factors in residents of city of Sao Pulo. Large cross-sectional health survey. Diet was assessed by 24-Hour dietary recalls and food propensity questionnaire. DNA will be extracted by salt method. Polymorphic variants will be identified by allele-specific PCR. The cancer risk will be analyzed by DNA adducts and malondialdehyde. Generalized Linear Models in STATA® will be used and P < 0.05 will be considered statistically significant. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CARVALHO, ALINE MARTINS; FALCAO DE OLIVEIRA, ANTONIO ANAX; DE MELO LOUREIRO, ANA PAULA; FIGARO GATTAS, GILKA JORGE; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Arginine intake is associated with oxidative stress in a general population. NUTRITION, v. 33, p. 211-215, JAN 2017. Web of Science Citations: 3.
DE CARVALHO, ALINE MARTINS; FERREIRA CARIOCA, ANTONIO AUGUSTO; FISBERG, REGINA MARA; QI, LU; MARCHIONI, DIRCE MARIA. Joint association of fruit, vegetable, and heterocyclic amine intake with DNA damage levels in a general population. NUTRITION, v. 32, n. 2, p. 260-264, FEB 2016. Web of Science Citations: 4.
CARVALHO, A. M.; MIRANDA, A. M.; SANTOS, F. A.; LOUREIRO, A. P. M.; FISBERG, R. M.; MARCHIONI, D. M. High intake of heterocyclic amines from meat is associated with oxidative stress. BRITISH JOURNAL OF NUTRITION, v. 113, n. 8, p. 1301-1307, APR 28 2015. Web of Science Citations: 13.

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