Promotion of healthy lifestyle in patients with Systemic Lupus Erythematosus: assessment of safety, efficiency and feasibility of the study 'Vivendo bem com Lúpus' (Living well with Lupus)

• Grant number: 19/14819-8
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2020
• End date: August 31, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Bruno Gualano
• Grantee: Fabiana Infante Smaira
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 23/07265-1 - Promotion of a healthy lifestyle in patients with systemic lupus erythematosus: safety, efficacy and feasibility of the study Living Well With Lupus, BE.EP.DD

Abstract

Patients with Systemic Lupus Erythematosus spend most of their daily hours in sedentary behavior and tend to be inactive. Sedentary behavior and physical inactivity are independent risk factors for poorer markers of health and mortality in the general population and in clinical cases. In addition, the food pattern is a determining factor in the individuals' health. Due to the lack of studies on the dietary pattern of patients with Systemic Lupus Erythematosus, it is believed that these patients present the same feeding profile of the general population, which is, high consumption of foods with unbalanced nutritional composition and high caloric density, characterized by an inadequate supply of micronutrients. In this context, new interventions focused on the practice of physical activity and food consumption management would be of great therapeutic relevance. However, to date, there are no studies focused on these strategies in patients with Systemic Lupus Erythematosus. Therefore, it is fundamental to evaluate the lifestyle changes resulting from a new intervention proposal. Thence, this project aims to: assess the safety, efficacy, and viability of clinical intervention, as well as the barriers and facilitators for engagement in lifestyle changes. It is a randomized, parallel group, controlled clinical study in which the following pre and post-intervention data will be collected: 1) sedentary behavior parameters and level of physical activity; 2) eating habits; 3) clinical parameters; 4) safety parameters and intervention feasibility. In addition, focus groups will be carried out at the end of the follow-up in order to qualitatively assess the impacts of the intervention. The findings of this project will be of great clinical relevance once they can serve as a basis for new prescriptions focused on the change of food and physical activity habits, which are risk factors for patients with Lupus. (AU)

Scientific publications

(18)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

PECANHA, TIAGO; MEIRELES, KAMILA; PINTO, ANA JESSICA; NUNES REZENDE, DIEGO AUGUSTO; IRAHA, AMANDA YURI; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; KLUSER SALES, ALLAN ROBSON; BONFIGLIOLI, KARINA; DE SA-PINTO, ANA LUCIA; et al. Increased sympathetic and haemodynamic responses to exercise and muscle metaboreflex activation in post-menopausal women with rheumatoid arthritis. JOURNAL OF PHYSIOLOGY-LONDON, v. 599, n. 3, NOV 2020. (19/14819-8, 15/26937-4, 17/13552-2, 14/11671-6, 19/07150-4)

MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; ASTLEY, CAMILLA; IRAHA, AMANDA YURI; PINTO, ANA JESSICA; MARQUES, ISABELA GOUVEIA; CORDEIRO AMARANTE, MILLA; REZENDE, NATHALIA SAFFIOTI; SIECZKOWSKA, SOFIA MENDES; FRANCO, TATHIANE CHRISTINE; et al. Changes in Eating Habits and Sedentary Behavior During the COVID-19 Pandemic in Adolescents With Chronic Conditions. FRONTIERS IN PEDIATRICS, v. 9, DEC 13 2021. (19/20814-9, 19/14819-8, 19/14820-6, 16/00006-7, 17/13552-2, 19/15231-4, 15/03756-4, 15/26937-4)

MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; ESTEVES, GABRIEL PERRI; SANTO ANDRE, HELOISA C.; AMARANTE, MILLA CORDEIRO; CASTANHO, DANIELA; CAMPOS, KAREN; BENATTI, FABIANA BRAGA; PINTO, ANA JESSICA; ROSCHEL, HAMILTON; et al. Influence of Body Mass Index on Eating Habits and Food Choice Determinants Among Brazilian Women During the COVID-19 Pandemic. FRONTIERS IN NUTRITION, v. 8, JUL 12 2021. (20/07860-9, 17/13552-2, 15/26937-4, 19/14819-8, 19/14820-6)

ISABELA GOUVEIA MARQUES; CAMILLA ASTLEY; SOFIA MENDES SIECZKOWSKA; AMANDA YURI IRAHA; TATHIANE CHRISTINE FRANCO; FABIANA INFANTE SMAIRA; BRUNA CARUSO MAZZOLANI; LUANA CRISTINA DO AMARAL MIRANDA; BIANCA PIRES IHARA; ROSA MARIA R. PEREIRA; et al. Lessons learned from a home-based exercise program for adolescents with pre-existing chronic diseases during the COVID-19 quarantine in Brazil. Clinics, v. 76, 2021-06-28. (17/13552-2, 15/03756-4, 19/15231-4, 19/14819-8, 19/20814-9, 19/14820-6, 16/00006-7)

SANTINI, MARTIN HINDERMANN; SANTO ANDRE, HELOISA C.; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; ESTEVES, GABRIEL PERRI; LEITAO, ALICE ERWIG; GUALANO, BRUNO; ROSCHEL, HAMILTON. The role of nutrition background on motivations, barriers, and adherence to a vegan diet: A qualitative study of the vegan eating habits and nutritional evaluation survey (VEGAN-EatS). FOOD QUALITY AND PREFERENCE, v. 125, p. 9-pg., 2024-11-26. (19/14819-8, 17/13552-2, 19/14820-6, 22/02229-4, 20/07860-9)

GUALANO, BRUNO; SAAD, CARLA G. S.; SIECZKOWSKA, SOFIA M.; LEMES, ITALO RIBEIRO; DA SILVA, RAFAEL PIRES; PINTO, ANA J.; MAZZOLANI, BRUNA C.; SMAIRA, FABIANA, I; GIL, SAULO; OLIVEIRA-JUNIOR, GERSIEL; et al. Effect of an exercise bout before the booster dose of an inactivated SARS-CoV-2 vaccine on immunogenicity in immunocompromised patients. Journal of Applied Physiology, v. 132, n. 3, p. 7-pg., 2022-03-01. (19/15231-4, 17/13552-2, 17/23688-9, 15/26937-4, 20/04877-8, 19/14820-6, 19/14819-8, 15/03756-4)

SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; SIECZKOWSKA, SOFIA MENDES; ROMERO, MARINA; RIBEIRO, THAINA TOLEDO; AMARANTE, MILLA CORDEIRO; PASOTO, SANDRA; PINTO, ANA LUCIA DE SA; LIMA, FERNANDA RODRIGUES; BENATTI, FABIANA BRAGA; et al. Food consumption, physical activity and aerobic capacity in systemic lupus erythematosus patients with high cardiovascular risk. Clinics, v. 79, p. 7-pg., 2024-07-13. (19/14820-6, 19/15231-4, 20/07135-2, 19/14819-8, 17/13552-2)

PINTO, ANA J.; MEIRELES, KAMILA; PECANHA, TIAGO; MAZZOLANI, BRUNA C.; SMAIRA, I, FABIANA; REZENDE, DIEGO; BENATTI, FABIANA B.; RIBEIRO, ANA C. M.; PINTO, ANA L. S.; LIMA, FERNANDA R.; et al. Acute cardiometabolic effects of brief active breaks in sitting for patients with rheumatoid arthritis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 321, n. 6, p. E782-E794, DEC 2021. (19/14819-8, 19/14820-6, 17/13552-2, 16/23319-0, 15/26937-4, 18/19418-9)

ESTEVES, GABRIEL P.; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; SANTO ANDRE, HELOISA C.; IRAHA, AMANDA YURI; ASTLEY, CAMILLA; MARQUES, ISABELA GOUVEIA; AMARANTE, MILLA CORDEIRO; REZENDE, NATHALIA SAFFIOTI; SIECZKOWSKA, SOFIA MENDES; et al. Food consumption based on processing level (according to Nova system) during the COVID-19 pandemic among adolescents with immunocompromised conditions: a case-control study. FRONTIERS IN NUTRITION, v. 10, p. 9-pg., 2023-05-16. (21/02742-0, 19/14820-6, 17/13552-2, 15/26937-4, 20/07860-9, 15/03756-4, 20/02741-1, 19/20814-9, 16/00006-7, 19/14819-8, 19/15231-4)

SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; LEMES, ITALO RIBEIRO; DA SILVA, RAFAEL PIRES; PINTO, ANA J.; SIECZKOWSKA, SOFIA M.; AIKAWA, NADIA E.; PASOTO, SANDRA G.; MEDEIROS-RIBEIRO, ANA C.; SAAD, CARLA G. S.; et al. No Associations Between Physical Activity and Immunogenicity in SARS-CoV-2 Seropositive Patients With Autoimmune Rheumatic Diseases Prior to and After Vaccination. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. N/A, p. 4-pg., 2023-06-08. (17/23688-9, 19/14820-6, 17/13552-2, 15/26937-4, 15/03756-4, 20/04877-8, 19/14819-8, 19/15231-4)

GUALANO, BRUNO; SIECZKOWSKA, SOFIA M.; LEMES, ITALO RIBEIRO; DA SILVA, RAFAEL PIRES; PINTO, ANA J.; MAZZOLANI, BRUNA C.; SMAIRA, FABIANA I.; AIKAWA, NADIA E.; KUPA, LEONARD V. K.; PASOTO, SANDRA G.; et al. Physical Activity: A Strategy to Improve Antibody Response to a SARS-CoV-2 Vaccine Booster Dose in Patients With Autoimmune Rheumatic Diseases. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. 20, n. 4, p. 6-pg., 2023-03-03. (17/23688-9, 19/14820-6, 17/13552-2, 15/26937-4, 15/03756-4, 20/04877-8, 19/14819-8, 19/15231-4)

ESTEVES, GABRIEL P.; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; MENDES, ELIZABETH SILVA; DE OLIVEIRA, GABRIELA GUIMARAES; ROSCHEL, HAMILTON; GUALANO, BRUNO; PEREIRA, ROSA MARIA R.; DOLAN, EIMEAR. Nutritional recommendations for patients undergoing prolonged glucocorticoid therapy. RHEUMATOLOGY ADVANCES IN PRACTICE, v. 6, n. 2, p. 13-pg., 2022-05-06. (19/14820-6, 19/05616-6, 16/00006-7, 20/08637-1, 20/07860-9, 19/14819-8)

SIECZKOWSKA, SOFIA MENDES; SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; ROMERO, MARINA; PASOTO, SANDRA GOFINET; PINTO, ANA LUCIA DE SA; LIMA, FERNANDA RODRIGUES; DE OLIVEIRA, VICTOR RODRIGUES; UEDA, SERLI; BENATTI, FABIANA BRAGA; et al. A randomized controlled trial of an intervention promoting physical activity and healthy eating recommendations in systemic lupus erythematosus: the protocol study "Living Well with Lupus". RHEUMATOLOGY INTERNATIONAL, v. 43, n. 10, p. 12-pg., 2023-06-24. (17/13552-2, 19/14820-6, 19/15231-4, 19/14819-8)

SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; ESTEVES, GABRIEL PERRI; ANDRE, HELOISA C. SANTO; AMARANTE, MILLA CORDEIRO; CASTANHO, DANIELA FERNANDES; CAMPOS, KAREN JENNIFER DE; BENATTI, FABIANA BRAGA; PINTO, ANA JESSICA; ROSCHEL, HAMILTON; et al. Poor Eating Habits and Selected Determinants of Food Choice Were Associated With Ultraprocessed Food Consumption in Brazilian Women During the COVID-19 Pandemic. FRONTIERS IN NUTRITION, v. 8, MAY 13 2021. (19/14819-8, 20/07860-9, 17/13552-2, 15/26937-4, 19/14820-6)

SIECZKOWSKA, MENDES; SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; GUALANO, BRUNO; ROSCHEL, HAMILTON; PECANHA, TIAGO. Efficacy of home-based physical activity interventions in patients with autoimmune rheumatic diseases: A systematic review and meta-analysis. SEMINARS IN ARTHRITIS AND RHEUMATISM, v. 51, n. 3, p. 576-587, JUN 2021. (19/07150-4, 19/14820-6, 17/13552-2, 16/23319-0, 19/14819-8, 19/15231-4)

GUALANO, BRUNO; LEMES, ITALO R.; SILVA, RAFAEL P.; PINTO, ANA J.; MAZZOLANI, BRUNA C.; SMAIRA, FABIANA, I; SIECZKOWSKA, SOFIA M.; AIKAWA, NADIA E.; PASOTO, SANDRA G.; MEDEIROS-RIBEIRO, ANA C.; et al. Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases. BRAIN BEHAVIOR AND IMMUNITY, v. 101, p. 8-pg., 2022-03-01. (19/14819-8, 15/03756-4, 15/26937-4, 19/15231-4, 17/23688-9, 17/13552-2, 19/14820-6)

MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; SIECZKOWSKA, SOFIA MENDES; ROMERO, MARINA; ANDRE, HELOISA C. SANTO; PASOTO, SANDRA G.; PINTO, ANA LUCIA DE SA; LIMA, FERNANDA RODRIGUES; BENATTI, FABIANA BRAGA; ROSCHEL, HAMILTON; et al. Acceptability and impact of a lifestyle intervention for systemic lupus erythematosus: Qualitative analysis of living well with lupus study. Lupus, v. 34, n. 5, p. 10-pg., 2025-03-13. (19/14819-8, 19/15231-4, 17/13552-2, 19/14820-6, 22/02229-4)

SIECZKOWSKA, SOFIA MENDES; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; ROMERO, MARINA; PASOTO, SANDRA GOFINET; PINTO, ANA LUCIA DE SA; LIMA, FERNANDA RODRIGUES; DE OLIVEIRA, VICTOR RODRIGUES; UEDA, SERLI; BENATTI, FABIANA BRAGA; et al. Effects of a lifestyle intervention on cardiovascular risk factors in systemic lupus erythematosus patients: The study "Living well with lupus". CLINICAL RHEUMATOLOGY, v. 43, n. 3, p. 11-pg., 2024-01-27. (19/14820-6, 17/13552-2, 19/14819-8, 19/15231-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SMAIRA, Fabiana Infante. Promotion of healthy lifestyle in patients with systemic lupus erythematosus: assessment of safety, efficiency and feasibility of the study \VIVENDO BEM COM LÚPUS\ (LIVING WELL WITH LUPUS). 2024. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.