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The effects of endurance exercise on the inflammatory profile and insulin sensitivity in women with systemic lupus erithematosus

Abstract

Systemic lupus erithematosus (SLE) is a systemic autoimune disease of unknown etiology. The main manifestations of the disease are due to a chronic inflammatory process which is associated with the increased prevalence of insulin resistance (IR) in SLE patients. It is well established that a physically active life may benefit the chronic inflammatory process and IR. The present study will be divided in two clinical essays. The aim of the first study is to verify the acute response of pro and anti-inflammatory cytokines to a moderate and to a vigorous intensity exercise session. The aim of the second study is to verify the chronic effects of an endurance training program on insulin sensitivity and on the pro and anti-inflammatory cytokine response. Female SLE patients from the Rheumatology Ambulatory of HC-FMUSP will be studied. In the acute study, 15 patients with SLE in activity (LESATIV), 15 patients with SLE out of activity (LESINATIV) and 15 healthy control subjects (CS1) will participate. All of the groups will be submitted to two endurance exercise sessions (moderate and vigorous intensity) to verify the pro and anti-inflammatory cytokine response, which will be assessed at rest, at peak exercise, every 30 min until 3 hours and 24 hours after the exercise cessation. In the chronic study, 30 SLE patients and 15 healthy control subjects (CS2) will participate. SLE patients will be randomized in two groups: trained (LT) and non-trained (LS). At baseline (PRE) and 12 weeks after the training (POS), LT and LS will be assessed for insulin sensitivity, disease activity and quality of life, physical capacity, dietary intake, body composition, leptin, adiponectin, resistin, visfatin and cytokine blood level, and protein expression of insulin signaling cascade members, and GLUT-4 translocation. Healthy control subjects will be matched for age and BMI and will be assessed at baseline only. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BENATTI, FABIANA B.; MIYAKE, CINTIA N. H.; DANTAS, WAGNER S.; ZAMBELLI, VANESSA O.; SHINJO, SAMUEL K.; PEREIRA, ROSA M. R.; SILVA, MARIA ELIZABETH R.; SA-PINTO, ANA LUCIA; BORBA, EDUARDO; BONFA, ELOISA; GUALANO, BRUNO. Exercise Increases Insulin Sensitivity and Skeletal Muscle AMPK Expression in Systemic Lupus Erythematosus: A Randomized Controlled Trial. FRONTIERS IN IMMUNOLOGY, v. 9, APR 27 2018. Web of Science Citations: 3.
MIYAKE, CINTIA N. H.; GUALANO, BRUNO; DANTAS, WAGNER S.; PEREIRA, RENATO T.; NEVES, WILLIAM; ZAMBELLI, VANESSA O.; SHINJO, SAMUEL K.; PEREIRA, ROSA M.; SILVA, ELIZABETH R.; SA-PINTO, ANA LUCIA; BORBA, EDUARDO; ROSCHEL, HAMILTON; BONFA, ELOISA; BENATTI, FABIANA B. Increased Insulin Resistance and Glucagon Levels in Mild/Inactive Systemic Lupus Erythematosus Patients Despite Normal Glucose Tolerance. ARTHRITIS CARE & RESEARCH, v. 70, n. 1, p. 114-124, JAN 2018. Web of Science Citations: 4.
PINTO, ANA J.; MIYAKE, CINTIA N. H.; BENATTI, FABIANA B.; SILVA, CLOVIS A.; SALLUM, ADRIANA M. E.; BORBA, EDUARDO; DE SA-PINTO, ANA L.; BONFA, ELOISA; GUALANO, BRUNO. Reduced Aerobic Capacity and Quality of Life in Physically Inactive Patients With Systemic Lupus Erythematosus With Mild or Inactive Disease. ARTHRITIS CARE & RESEARCH, v. 68, n. 12, p. 1780-1786, DEC 2016. Web of Science Citations: 12.
BENATTI, FABIANA BRAGA; MIOSSI, RENATA; PASSARELI, MARISA; NAKANDAKARE, EDNA R.; PERANDINI, LUIZ; LIMA, FERNANDA RODRIGUES; ROSCHEL, HAMILTON; BORBA, EDUARDO; BONFA, ELOISA; GUALANO, BRUNO; DE SA PINTO, ANA LUCIA. The effects of exercise on lipid profile in systemic lupus erythematosus and healthy individuals: a randomized trial. RHEUMATOLOGY INTERNATIONAL, v. 35, n. 1, p. 61-69, JAN 2015. Web of Science Citations: 5.
PERANDINI, L. A.; SALES-DE-OLIVEIRA, D.; MELLO, V, S. B.; CAMARA, N. O.; BENATTI, F. B.; LIMA, F. R.; BORBA, E.; BONFA, E.; ROSCHEL, H.; SA-PINTO, A. L.; GUALANO, B. Inflammatory cytokine kinetics to single bouts of acute moderate and intense aerobic exercise in women with active and inactive systemic lupus erythematosus. EXERCISE IMMUNOLOGY REVIEW, v. 21, p. 174-185, 2015. Web of Science Citations: 13.
PERANDINI, LUIZ A.; SALES-DE-OLIVEIRA, DIEGO; MELLO, SUZANA B. V.; CAMARA, NIELS O.; BENATTI, FABIANA B.; LIMA, FERNANDA R.; BORBA, EDUARDO; BONFA, ELOISA; SA-PINTO, ANA L.; ROSCHEL, HAMILTON; GUALANO, BRUNO. Exercise training can attenuate the inflammatory milieu in women with systemic lupus erythematosus. Journal of Applied Physiology, v. 117, n. 6, p. 639-647, SEP 15 2014. Web of Science Citations: 18.
PERANDINI, LUIZ AUGUSTO; DE SA-PINTO, ANA LUCIA; ROSCHEL, HAMILTON; BENATTI, FABIANA BRAGA; LIMA, FERNANDA RODRIGUES; BONFA, ELOISA; GUALANO, BRUNO. Exercise as a therapeutic tool to counteract inflammation and clinical symptoms in autoimmune rheumatic diseases. AUTOIMMUNITY REVIEWS, v. 12, n. 2, SI, p. 218-224, DEC 2012. Web of Science Citations: 42.

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