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Effect of interval training on serum adipokine levels in patients with systemic lupus erythematosus

Grant number: 18/14330-6
Support type:Regular Research Grants
Duration: June 01, 2019 - May 31, 2021
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Edgard Torres dos Reis Neto
Grantee:Edgard Torres dos Reis Neto
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers:Emilia Inoue Sato ; Washington dos Santos Oliveira


Background: with improved treatment and decreased mortality in the last decades, atherosclerotic vascular disease and its complications have been identified as an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Studies have shown a correlation between adipokine levels and cardiovascular risk factors, with possible immunomodulatory role of these cytokines by mediating immune system, lipid metabolism and atherosclerosis. Although it is established in the literature that SLE patients can benefit from regular physical exercise and that physical exercise modify the profile of some adipokines in some diseases such as metabolic syndrome, diabetes and hypertension, there are no studies that have evaluated the effect of physical exercise on adipokine serum levels in SLE patients. Objectives: to evaluate the effect of high intensity interval aerobic training on the serum levels of leptin, adiponectin, visfatin, resistin and quemerin in patients with SLE. Secondary objectives: to evaluate the effect of high intensity interval aerobic training on body composition and to correlate adipokine levels studied with body composition parameters before and after physical exercise. Patients and methods: prospective, randomized study, in which 72 patients with SLE (SLICC criteria, 2012) will be allocated in exercise group (GE) and control group (CG) according to the randomization table. All evaluations will be performed at baseline (T0) and at the end of 12 weeks (T12) in both groups by blind assessors. Intervention: GE will conduct a 12-week, 3-week, 60-minute exercise program (10 warm-up, 40 high-intensity interval aerobic training and 10 cool-down) at the Unifesp Sports Medicine Academy supervised by a physical educator or a physician. The training will be prescribed by the maximum heart rate obtained previously in the ergospirometric test and participants will be monitored by heart rate. The CG will be advised not to start physical exercise for 12 weeks and is invited to perform the exercise program after this period. Serum levels of leptin, visfatin, resistin, quemerine and adiponectin by Multiplex Luminex (R & D Systems, Minneapolis, MN, USA) will be analyzed in T0 and T12 and the body composition will be evaluated using the dual emission densitometer with lightning source X (Lunar Radiation Corporation, DPX model, Madison, WI, USA). SLE disease activity will be assessed by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) -ACR. Damage will be measured in the T0 by The Systemic Lupus International Collaborating Clinics / American College of Rheumatology Damage Index for Systemic Lupus Erythematosus (SLICC / ACR-DI). Level of physical activity in the EG and GC will be assessed by the International Physical Activity Questionnaire (IPAQ). Patients will complete a three-day food diary on T0 and T12. Statistical analysis: normality test, Student t test; non-parametric tests for data with non-normal distribution. Pearson or Spearman correlation. Values of p <0.05 will be considered significant. (AU)