The effects of short-term combined exercise training on telomere length in obese women: a prospective, interventional study

Autor(es)

Cunha Brandao, Camila Fernanda ^[1] ; Nonino, Carla Barbosa ^{[2, 1]} ; de Carvalho, Flavia Giolo ^[3] ; Nicoletti, Carolina Ferreira ^[1] ; Noronha, Natalia Yumi ^[1] ; San Martin, Rocio ^[1] ; de Freitas, Ellen Cristini ^[3] ; Morandi Junqueira-Franco, Marcia Varella ^[1] ; Marchini, Julio Sergio ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Internal Med Dept, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Hlth Sci, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SPORTS MEDICINE-OPEN; v. 6, n. 1 JAN 16 2020.
• Citações Web of Science: 0

Resumo

Background Telomere length is inversely associated with the senescence and aging process. Parallelly, obesity can promote telomere shortening. Evidence suggests that physical activity may promote telomere elongation. Objective This study's objective is to evaluate the effects of combined exercise training on telomere length in obese women. Design and Methods Twenty pre-menopausal women (BMI 30-40 kg/m(2), 20-40 years) submitted to combined training (strength and aerobic exercises), but only 13 finished the protocol. Each exercise session lasted 55 min/day, three times a week, throughout 8 weeks. Anthropometric data, body composition, physical performance (Vo(2max)), and 8-h fasting blood samples were taken before and after 8 weeks of training. Leukocyte DNA was extracted for telomere length by RT-qPCR reaction, using the 2(-Delta Delta Ct) methodology. Results After the training intervention, significant differences (p < 0.05) were observed in telomere length (respectively before and after, 1.03 +/- 0.04 to 1.07 +/- 0.04 T/S ratio), fat-free mass (46 +/- 7 to 48 +/- 5 kg), Vo(2max) (35 +/- 3 to 38 +/- 3 ml/kg/min), and waist circumference (96 +/- 8 to 90 +/- 6 cm). In addition, an inverse correlation between waist circumference and telomere length was found, before (r = - 0.536, p = 0.017) and after (r = - 0.655, p = 0.015) exercise training. Conclusion Combined exercise promoted leukocyte telomere elongation in obese women. Besides, the data suggested that greater waist circumference may predict shorter telomere length. (AU)

• Processo FAPESP: 17/10080-2 - Metabolismo energético mitocondrial, inflamação e estresse oxidativo em mulheres obesas submetidas a suplementação de taurina associado ao treinamento físico
• Beneficiário: Ellen Cristini de Freitas
• Modalidade de apoio: Auxílio à Pesquisa - Regular