Evaluating the FEV1/FVC ratio in the lower range of normality as a marker of worse clinical outcomes in asthmatic subjects without airway obstruction

Autor(es)

Mingotti, Cintia ^[1] ; Sarinho, Jose ^[1] ; Stanigher, Katia ^[1] ; Silva, Jucara ^[1] ; Roquette, Eduardo ^[1] ; Marchi, Evaldo ^[1] ; Ponte, Eduardo Vieira ^[1]

Afiliação do(s) autor(es)

^[1] Fac Med Jundiai, Dept Internal Med, Jundiai, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: RESPIRATORY MEDICINE; v. 162, FEB 2020.
• Citações Web of Science: 0

Resumo

Background: We should continually improve tools for evaluating asthma. The aim of this study was to evaluate whether the FEV1/FVC ratio in the lower range of normality is associated with worse outcomes in asthmatics without airway obstruction. Methods: We screened asthmatics at eight clinics. Subjects answered the Asthma Control Questionnaire and underwent spirometry. We assigned individuals without airway obstruction in three groups according to the post bronchodilator FEV1/FVC ratio: lower range of normality, intermediary range of normality and upper range of normality. Asthma outcomes were hospital admission due to asthma during the preceding year, non-controlled asthma symptoms and moderate-high inhaled maintenance therapy need. Results: In subjects from six to 18 years old, the rate of hospital admission was higher in the group with FEV1/FVC ratio in the lower range of normality as compared with the other two groups but the frequency of non-controlled symptoms of asthma and moderate-high dose of inhaled maintenance therapy need was similar. From 19 to 59 years old, the rate of moderate-high inhaled maintenance therapy need was higher in the group with FEV1/FVC ratio in the lower range of normality as compared with the other two groups, but the frequency of hospital admissions and non-controlled symptoms of asthma was similar. Above 59 years old, there was no difference in clinical asthma outcomes between lung function groups. Conclusions: FEV1/FVC ratio in the lower range of normality is a marker of worse clinical outcomes in asthmatics without airway obstruction. (AU)

• Processo FAPESP: 17/18367-9 - Fatores de risco para perda acelerada de função pulmonar, obstrução irreversível de vias aéreas e doença refratária em indivíduos com asma
• Beneficiário: Eduardo Vieira Ponte
• Modalidade de apoio: Auxílio à Pesquisa - Regular