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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluating the FEV1/FVC ratio in the lower range of normality as a marker of worse clinical outcomes in asthmatic subjects without airway obstruction

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Author(s):
Mingotti, Cintia [1] ; Sarinho, Jose [1] ; Stanigher, Katia [1] ; Silva, Jucara [1] ; Roquette, Eduardo [1] ; Marchi, Evaldo [1] ; Ponte, Eduardo Vieira [1]
Total Authors: 7
Affiliation:
[1] Fac Med Jundiai, Dept Internal Med, Jundiai, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: RESPIRATORY MEDICINE; v. 162, FEB 2020.
Web of Science Citations: 0
Abstract

Background: We should continually improve tools for evaluating asthma. The aim of this study was to evaluate whether the FEV1/FVC ratio in the lower range of normality is associated with worse outcomes in asthmatics without airway obstruction. Methods: We screened asthmatics at eight clinics. Subjects answered the Asthma Control Questionnaire and underwent spirometry. We assigned individuals without airway obstruction in three groups according to the post bronchodilator FEV1/FVC ratio: lower range of normality, intermediary range of normality and upper range of normality. Asthma outcomes were hospital admission due to asthma during the preceding year, non-controlled asthma symptoms and moderate-high inhaled maintenance therapy need. Results: In subjects from six to 18 years old, the rate of hospital admission was higher in the group with FEV1/FVC ratio in the lower range of normality as compared with the other two groups but the frequency of non-controlled symptoms of asthma and moderate-high dose of inhaled maintenance therapy need was similar. From 19 to 59 years old, the rate of moderate-high inhaled maintenance therapy need was higher in the group with FEV1/FVC ratio in the lower range of normality as compared with the other two groups, but the frequency of hospital admissions and non-controlled symptoms of asthma was similar. Above 59 years old, there was no difference in clinical asthma outcomes between lung function groups. Conclusions: FEV1/FVC ratio in the lower range of normality is a marker of worse clinical outcomes in asthmatics without airway obstruction. (AU)

FAPESP's process: 17/18367-9 - RISK FACTORS FOR RAPID LOSS OF LUNG FUNCTION, IRREVERSIBLE AIRWAY OBSTRUCTION AND REFRACTORY DISEASE IN SUBJECTS WITH ASTHMA
Grantee:Eduardo Vieira Ponte
Support Opportunities: Regular Research Grants