RISK FACTORS FOR RAPID LOSS OF LUNG FUNCTION, IRREVERSIBLE AIRWAY OBSTRUCTION AND REFRACTORY DISEASE IN SUBJECTS WITH ASTHMA

• Grant number: 17/18367-9
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2019
• End date: January 31, 2021
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Eduardo Vieira Ponte
• Grantee: Eduardo Vieira Ponte
• Host Institution: Faculdade de Medicina de Jundiaí (FMJ). Prefeitura Municipal de Jundiaí. Jundiaí , SP, Brazil
• Associated researchers: Evaldo Marchi

Abstract

Introduction: Identify risk factors for refractory asthma, rapid loss of lung function and irreversible airway obstruction in subjects with asthma contributes to understand the causes and prevent these conditions. Aims: Identify risk factors for refractory asthma, rapid loss of lung function and irreversible airway obstruction in subjects with asthma. Methods: This is a one-year prospective study. Inclusion criteria were asthma diagnosis, age above 10 years old, six months of follow up with a chest physician, three months of regular use of inhaled corticosteroids and sign informed consent. There will be five study visits. V1 is the enrollment visit. The interval between visits will be three months. We will apply questionnaires to measure symptoms control, the characteristics of asthma and environment exposures. Subjects will perform lung function test, and we will collect peripheral blood to count eosinophils and measure total serum IgE. The chest physician will adjust treatment every study visit according to the study protocol. We will perform logistic regression models to identify risk factors for refractory asthma, irreversible airway obstruction and rapid loss of lung function. The status of refractory asthma, irreversible airway obstruction and rapid loss of lung function will be defined according to the condition of the patient in the last study visit. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PONTE, EDUARDO VIEIRA; MINGOTTI, CINTIA FERNANDA BERTAGNI; MAMONI, RONEI LUCIANO; MARCHI, EVALDO; MARTINELLI, JOSE EDUARDO; DE MENEZES, MARCELO BEZERRA; VIANNA, ELCIO DOS SANTOS OLIVEIRA; CRUZ, ALVARO AUGUSTO. Hospital admission rate in children and adolescents with mild persistent asthma. PEDIATRIC PULMONOLOGY, v. 56, n. 7, MAR 2021. (17/18367-9)

SILVA, JUCARA NOELI; ROCHA, ALCIDES; DE SOUZA, IVANI APARECIDA; ATHANAZIO, RODRIGO; PONTE, EDUARDO VIEIRA. Does peripheral blood eosinophil count predict lung function improvement in adult subjects with asthma?. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, v. 127, n. 3, p. 388+, SEP 2021. (17/18367-9)

SILVA, JUCARA NOELI; ROCHA, ALCIDES; SOUZA, IVANI APARECIDA; ATHANAZIO, RODRIGO; PONTE, EDUARDO VIEIRA. Does peripheral blood eosinophil count predict lung function improvement in adult subjects with asthma?. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, v. 127, n. 3, p. 388-389, SEP 2021. (17/18367-9)

PONTE, V, EDUARDO; MINGOTTI, CINTIA B.; SOUZA-MACHADO, CAROLINA; SILVA, JUCARA N.; CHEQUI, LUCAS; ARBEX, FLAVIO F.; ROCHA, ALCIDES; CRUZ, ALVARO A.. Comparing hospital admissions, comorbidities, and biomarkers between severe asthma and Gold III-IV chronic obstructive pulmonary disease. CLINICAL RESPIRATORY JOURNAL, AUG 2021. (17/18367-9)

MINGOTTI, CINTIA; SARINHO, JOSE; STANIGHER, KATIA; SILVA, JUCARA; ROQUETTE, EDUARDO; MARCHI, EVALDO; PONTE, EDUARDO VIEIRA. Evaluating the FEV1/FVC ratio in the lower range of normality as a marker of worse clinical outcomes in asthmatic subjects without airway obstruction. RESPIRATORY MEDICINE, v. 162, FEB 2020. (17/18367-9)

PONTE, EDUARDO VIEIRA; FANELLI, MARCELO FERRETTI; RODRIGUES FERREIRA, RENATA TOSONI; PEREIRA, JULIANA FRANCESCHINI; SOARES E SILVA ALCADIPANE, MARILIA; DE LIMA, VALMAR BIAO; MARCHI, EVALDO; DOS SANTOS, RICARDO SALES. Lung Cancer Mortality and the Availability of Chest Computerized Tomography: A Longitudinal Nationwide Study. CANCER INVESTIGATION, v. 38, n. 5, MAY 2020. (17/18367-9)

LUIZA OLIVEIRA NICASTRO SOARES; EDNA EURIDES THEODORO; MARIANA MELO ANGELELLI; LARISSA LUHI LIN; GIULIA ROCHA CARCHEDI; CATARINA CEOLIN SILVA; DANIEL GIMENEZ DA ROCHA; EDUARDO VIEIRA PONTE. Evaluating the effect of childhood and adolescence asthma on the household economy. Jornal de Pediatria, v. 98, n. 5, p. 490-495, 2022-10-24. (17/18367-9)

SILVA, JUCARA NOELI; ROCHA, ALCIDES; SOUZA, IVANI APARECIDA; ATHANAZIO, RODRIGO; PONTE, EDUARDO VIEIRA. Does peripheral blood eosinophil count predict lung function improvement in adult subjects with asthma?. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, v. 127, n. 3, p. 2-pg., 2021-09-01. (17/18367-9)

PONTE, EDUARDO VIEIRA; DA ROCHA, DANIEL GIMENEZ; GUINOSSI, RAISSA MARTINS; BERTOCHE, LAIS; BERTOLINO, JESSICA REGINA; BELLEZE, LETICIA; GALASTRI, ANA LUCIA BERGAMASCO; MAMONI, RONEI LUCIANO. Evaluating the relationship between the type of rescue medication and the adequacy of asthma maintenance therapy. RESPIRATORY MEDICINE, v. 217, p. 5-pg., 2023-10-01. (17/18367-9)