| Texto completo | |
| Autor(es): |
Shishido, Tania Keiko
[1, 2]
;
Popin, Rafael Vicentini
[1]
;
Jokela, Jouni
[1]
;
Wahlsten, Matti
[1]
;
Fiore, Marli Fatima
[3]
;
Fewer, David P.
[1]
;
Herfindal, Lars
[4]
;
Sivonen, Kaarina
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Helsinki, Dept Microbiol, Viikinkaari 9, FI-00014 Helsinki - Finland
[2] Univ Helsinki, Inst Biotechnol, Viikinkaari 5D, FI-00014 Helsinki - Finland
[3] Univ Sao Paulo, Ctr Nucl Energy Agr, Ave Centenario 303, BR-13400970 Piracicaba, SP - Brazil
[4] Univ Bergen, Ctr Pharm, Dept Clin Sci, POB 7804, N-5020 Bergen - Norway
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | TOXINS; v. 12, n. 1 JAN 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments. (AU) | |
| Processo FAPESP: | 13/50425-8 - Biodiversity of cyanobacteria and their bioactive compounds from under-explored Brazilian habitats |
| Beneficiário: | Marli de Fátima Fiore |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |