Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

Full text
Author(s):
Shishido, Tania Keiko [1, 2] ; Popin, Rafael Vicentini [1] ; Jokela, Jouni [1] ; Wahlsten, Matti [1] ; Fiore, Marli Fatima [3] ; Fewer, David P. [1] ; Herfindal, Lars [4] ; Sivonen, Kaarina [1]
Total Authors: 8
Affiliation:
[1] Univ Helsinki, Dept Microbiol, Viikinkaari 9, FI-00014 Helsinki - Finland
[2] Univ Helsinki, Inst Biotechnol, Viikinkaari 5D, FI-00014 Helsinki - Finland
[3] Univ Sao Paulo, Ctr Nucl Energy Agr, Ave Centenario 303, BR-13400970 Piracicaba, SP - Brazil
[4] Univ Bergen, Ctr Pharm, Dept Clin Sci, POB 7804, N-5020 Bergen - Norway
Total Affiliations: 4
Document type: Journal article
Source: TOXINS; v. 12, n. 1 JAN 2020.
Web of Science Citations: 0
Abstract

Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments. (AU)

FAPESP's process: 13/50425-8 - Biodiversity of cyanobacteria and their bioactive compounds from under-explored Brazilian habitats
Grantee:Marli de Fátima Fiore
Support Opportunities: Regular Research Grants