Mathematical model of the immune response to dengue virus

Autor(es)

Ceron Gomez, Miller ^[1] ; Yang, Hyun Mo ^[2]

Afiliação do(s) autor(es)

^[1] Univ Narino, Calle 18 Carrera 50, Torobajo, Pasto - Colombia

^[2] Univ Estadual Campinas, Cidade Univ Zeferino Vaz, BR-13083970 Campinas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF APPLIED MATHEMATICS AND COMPUTING; v. 63, n. 1-2 FEB 2020.
• Citações Web of Science: 0

Resumo

Dengue disease is caused by an infected mosquito bite and manifests in different clinical symptoms. The complexity of the pathogenesis of dengue virus and the limitations of biological knowledge have been barriers to completely understanding the progress of this disease. To address this concern, we developed a mathematical model of the immune response to eliminate dengue virus. The model considered both cellular and humoral immune responses, and we evaluated their contributions to the clearance of dengue virus.We also performed global sensitivity analysis and parameters estimation using clinical data. We found the global stability for virus-free equilibrium and for the virus-presence equilibrium, we concluded that to avoid oscillations in the model and to control the viral load, a strong proliferation of cytotoxic cells must prevail. However, if there exists a weak proliferation of cytotoxic cells, the way to avoid instabilities is to either inhibit the differentiation of T-CD4+ helper cells in Th1 cells or increase the proliferation of B cells. (AU)

• Processo FAPESP: 13/17264-0 - Modelagem da Resposta do Hospedeiro ao Vírus da Dengue e Reforço Dependente de Anticorpos
• Beneficiário: Miller Orlando Cerón Gómez
• Modalidade de apoio: Bolsas no Brasil - Doutorado