| Full text | |
| Author(s): |
Total Authors: 2
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| Affiliation: | [1] Univ Narino, Calle 18 Carrera 50, Torobajo, Pasto - Colombia
[2] Univ Estadual Campinas, Cidade Univ Zeferino Vaz, BR-13083970 Campinas - Brazil
Total Affiliations: 2
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| Document type: | Journal article |
| Source: | JOURNAL OF APPLIED MATHEMATICS AND COMPUTING; v. 63, n. 1-2 FEB 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Dengue disease is caused by an infected mosquito bite and manifests in different clinical symptoms. The complexity of the pathogenesis of dengue virus and the limitations of biological knowledge have been barriers to completely understanding the progress of this disease. To address this concern, we developed a mathematical model of the immune response to eliminate dengue virus. The model considered both cellular and humoral immune responses, and we evaluated their contributions to the clearance of dengue virus.We also performed global sensitivity analysis and parameters estimation using clinical data. We found the global stability for virus-free equilibrium and for the virus-presence equilibrium, we concluded that to avoid oscillations in the model and to control the viral load, a strong proliferation of cytotoxic cells must prevail. However, if there exists a weak proliferation of cytotoxic cells, the way to avoid instabilities is to either inhibit the differentiation of T-CD4+ helper cells in Th1 cells or increase the proliferation of B cells. (AU) | |
| FAPESP's process: | 13/17264-0 - Modeling the Host Response to Dengue Virus and Antibody Dependent Enhancement |
| Grantee: | Miller Orlando Cerón Gómez |
| Support Opportunities: | Scholarships in Brazil - Doctorate |