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A review on polyphosphate coacervates-structural properties and bioapplications

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Franco, Douglas F. [1] ; De Oliveira Barud, Helida G. [2, 3] ; Barud, Hernane S. [4, 5] ; Oliveira Junior, Osmir B. [2] ; Meneguin, Andreia B. [4, 5] ; de Oliveira, Luiz Fernando C. [6] ; Silva, Mauricio A. P. [6] ; Ribeiro, Sidney J. L. [1] ; Nalin, Marcelo [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Inst Quim, POB 355, BR-14801970 Araraquara, SP - Brazil
[2] Sao Paulo State Univ, Sch Dent, UNESP, Rua Humaita 1680, BR-14801903 Araraquara, SP - Brazil
[3] BioSmart Nanotechnol LTDA, Ave Jorge Fernandes de Mattos 311, BR-14808162 Araraquara, SP - Brazil
[4] Ctr Univ Araraquara UNIARA, Araraquara, SP - Brazil
[5] Lab Biopolimeros & Biomat BioPolMat, Araraquara, SP - Brazil
[6] Univ Fed Juiz de Fora, NEEM, Dept Quim, Inst Ciencias Exatas, BR-36036900 Juiz De Fora, MG - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo de Revisão
Fonte: Journal of Sol-Gel Science and Technology; v. 94, n. 3 JAN 2020.
Citações Web of Science: 0

The coacervation process of Graham's Salt Na(PO3)(n) enabled the preparation of polyphosphate coacervates (CPPs) by adding different metallic ions (Mn+), and/or low-molecular-weight solvents at a specific solution, which resulted in a phase separation. The more viscous phase is termed as CPP and the less viscous one is the supernatant. CPPs have been extensively studied in recent years as a glass precursor at room temperature. Preparation at room temperature allows the preservation of the physicochemical properties of a wide range of active principles that may be used in controlled drug-delivery systems. Despite the present limitations of CPPs in terms of high hygroscopicity, this vulnerability to water is considered one of the great advantages of this material regarding applications in the controlled release of drugs and tissue engineering. Thus, in the presence of water, CPPs will dissolve in calcium and phosphate ions, which are the major inorganic constituents of bone and hydroxyapatite (HAP). It is believed that, in contact with body fluids, CPPs will degrade and, as this process occurs, they will be replaced by HAP. Therefore, CPPs configure a potential biomaterial that offers excellent properties with a wide range of biomedical applications that will be discussed and reviewed in this paper, including the structural properties and the recent improvements of materials based on CPPs and related devices. {[}GRAPHICS] . (AU)

Processo FAPESP: 13/07793-6 - CEPIV - Centro de Ensino, Pesquisa e Inovação em Vidros
Beneficiário:Edgar Dutra Zanotto
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 16/16900-9 - Preparação de fibras de vidros óxidos de metal pesado com propriedades ópticas e magneto-ópticas
Beneficiário:Douglas Faza Franco
Linha de fomento: Bolsas no Brasil - Pós-Doutorado