Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers

Autor(es)

Campos, Isabelle ^[1] ; Espindola, Ariane ^[1] ; Chagas, Camila ^[2] ; Barbosa, Emerson ^[2] ; Castro, Carlos E. ^[3] ; Molina, Celso ^[1] ; Fonseca, Fernando L. A. ^{[1, 2]} ; Haddad, Paula S. ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Dept Chem, Diadema, SP - Brazil

^[2] Fac Med ABC FMABC, Santo Andre, SP - Brazil

^[3] Fed Univ ABC UFABC, CCNH, Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SN APPLIED SCIENCES; v. 2, n. 3 MAR 2020.
• Citações Web of Science: 0

Resumo

This article describes the synthesis, characterization, in vitro cytotoxic and genotoxicity evaluation of chitosan-iron oxide nanoparticles (Fe3O4-CS) as vehicles for ibuprofen (IBU) molecule. Magnetite (Fe3O4) nanoparticles were synthesized by co-precipitation of iron salts and coated with chitosan, leading to the formation of Fe3O4-CS hybrid nanoparticles, and then IBU was adsorbed on the surface of the modified nanoparticles.The physicochemical, morphological, and magnetic properties of the nanoparticles were determined by X-ray powder diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy and SQUID magnetic measurements. The nanoparticles have shown stability in aqueous medium presenting an average hydrodynamic size of 36 +/- 9 nm for Fe3O4-CS, and 132 +/- 1 nm for Fe3O4-CS-IBU. The cytotoxicity of nanoparticles using the cell viability of the blood mononuclear cell fraction and the analysis of gene expression of the repair genes hMSH2, hMSH6 and NF-kB were performed to evaluate their applicability as drug carriers. The results showed that Fe3O4-CS nanoparticles are suitable candidates as magnetic vehicles for ibuprofen in biomedical applications. {[}GRAPHICS] . (AU)

• Processo FAPESP: 18/12219-0 - Avaliação da toxicidade e ação antineoplásica em camundongos tipo BALB/c inoculados com Tumor de Ehrlich tratados com nanopartículas superparamagnéticas
• Beneficiário: Camila dos Santos Chagas
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/15061-6 - Preparação, Caracterização e Ensaios Biológicos de Materiais Nanoestruturados Baseados em Nanopartículas Superparamagnéticas Metálicas e Bimetálicas
• Beneficiário: Paula Silvia Haddad Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/22478-8 - Síntese, caracterização e ensaios biomédicos de nanopartículas de óxido de ferro
• Beneficiário: Isabelle de Souza Campos
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica