| Texto completo | |
| Autor(es): |
Soares, Ciro D.
[1]
;
Carlos, Roman
[2]
;
Mota, Marcelo V. B.
[3]
;
de Carvalho, Maria G. F.
[1]
;
de Lima Morais, Thayna M.
[1]
;
de Almeida, Oslei P.
[1]
;
Altemani, Albina
[3]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] State Univ Campinas UNICAMP, Piracicaba Dent Sch, Oral Pathol Dept, Campinas - Brazil
[2] Hosp Herrera Llerandi, Ctr Clin Cabeza & Cuello, Pathol Div, Guatemala City - Guatemala
[3] State Univ Campinas UNICAMP, Fac Med Sci, Pathol Dept, Campinas - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Histopathology; v. 76, n. 4, p. 613-624, MAR 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Aims The hallmarks of type 2 diabetes (T2D) are hyperglycaemia and insulin resistance. These factors, at the cellular level, are associated with mitochondrial dysfunction and increased glucose uptake. Such events are poorly explored in the context of the salivary glands. In this study, we present a series of eight cases of a distinct salivary gland lesion characterised by multiple oncocytic cysts, and we provide new pathological insights regarding its pathogenesis. Methods and results Seven patients (87.5%) had confirmed T2D, and obesity was identified in five (62.5%) patients. Clinically, the patients showed bilateral parotid gland swelling with recurrent episodes of pain and enlargement. Imaging examination revealed multiple cystic lesions in both parotid glands. Microscopically, the parotid glands showed multiple cysts of different sizes, lined by oncocytic epithelial cells. Intraluminally, strongly eosinophilic glass-like crystalloid material was observed. Immunohistochemical studies were performed, and the most notable finding was glucose transporter 1 (GLUT1) overexpression in the oncocytic cysts which is not observed in any other oncocytic lesion of patients without T2D. In addition, high expressions of mitochondrial antigen, fission 1 protein and mitofusin-2 were observed in the oncocytic epithelium of the cysts. Furthermore, most of the oncocytic cysts showed a pattern of cytokeratin expression consistent with striated ducts. Conclusions These results strongly suggest that T2D is associated with alterations in GLUT1 expression in the cells of striated ducts with mitochondrial dysfunction, causing a hyperplastic process characterised by multiple oncocytic cysts. For this lesion, the designation of `diabetes-associated-bilateral multiple oncocytic cysts of the parotid gland' is proposed. (AU) | |
| Processo FAPESP: | 17/16102-8 - Papel biológico de RUNX1, Akt, COX-2 e metaloproteinases no mecanismo de metástase em melanomas |
| Beneficiário: | Jacks Jorge Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/25905-1 - Expressão de Akt, COX-2, RUNX1 e metaloproteinases em melanomas metastáticos e Prospecção biotecnológica de moléculas com atividade antitumoral |
| Beneficiário: | Ciro Dantas Soares |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |