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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bilateral multiple oncocytic cysts of the parotid gland in type 2 diabetes patients

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Author(s):
Soares, Ciro D. [1] ; Carlos, Roman [2] ; Mota, Marcelo V. B. [3] ; de Carvalho, Maria G. F. [1] ; de Lima Morais, Thayna M. [1] ; de Almeida, Oslei P. [1] ; Altemani, Albina [3]
Total Authors: 7
Affiliation:
[1] State Univ Campinas UNICAMP, Piracicaba Dent Sch, Oral Pathol Dept, Campinas - Brazil
[2] Hosp Herrera Llerandi, Ctr Clin Cabeza & Cuello, Pathol Div, Guatemala City - Guatemala
[3] State Univ Campinas UNICAMP, Fac Med Sci, Pathol Dept, Campinas - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Histopathology; v. 76, n. 4, p. 613-624, MAR 2020.
Web of Science Citations: 0
Abstract

Aims The hallmarks of type 2 diabetes (T2D) are hyperglycaemia and insulin resistance. These factors, at the cellular level, are associated with mitochondrial dysfunction and increased glucose uptake. Such events are poorly explored in the context of the salivary glands. In this study, we present a series of eight cases of a distinct salivary gland lesion characterised by multiple oncocytic cysts, and we provide new pathological insights regarding its pathogenesis. Methods and results Seven patients (87.5%) had confirmed T2D, and obesity was identified in five (62.5%) patients. Clinically, the patients showed bilateral parotid gland swelling with recurrent episodes of pain and enlargement. Imaging examination revealed multiple cystic lesions in both parotid glands. Microscopically, the parotid glands showed multiple cysts of different sizes, lined by oncocytic epithelial cells. Intraluminally, strongly eosinophilic glass-like crystalloid material was observed. Immunohistochemical studies were performed, and the most notable finding was glucose transporter 1 (GLUT1) overexpression in the oncocytic cysts which is not observed in any other oncocytic lesion of patients without T2D. In addition, high expressions of mitochondrial antigen, fission 1 protein and mitofusin-2 were observed in the oncocytic epithelium of the cysts. Furthermore, most of the oncocytic cysts showed a pattern of cytokeratin expression consistent with striated ducts. Conclusions These results strongly suggest that T2D is associated with alterations in GLUT1 expression in the cells of striated ducts with mitochondrial dysfunction, causing a hyperplastic process characterised by multiple oncocytic cysts. For this lesion, the designation of `diabetes-associated-bilateral multiple oncocytic cysts of the parotid gland' is proposed. (AU)

FAPESP's process: 17/16102-8 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas
Grantee:Jacks Jorge Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 15/25905-1 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas and Biotechnology prospection of molecules with antineoplastic activity
Grantee:Ciro Dantas Soares
Support Opportunities: Scholarships in Brazil - Doctorate