Neurological disorders and mitochondria

Autor(es)

Cabral-Costa, J. V. ^[1] ; Kowaltowski, A. J. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: MOLECULAR ASPECTS OF MEDICINE; v. 71, FEB 2020.
• Citações Web of Science: 1

Resumo

The brain is highly dependent on mitochondrial energy metabolism. As a result, mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases, including stroke, ALS, Alzheimer's, Huntington's, and Parkinson's diseases. We review here how different mitochondrial functions, including oxidative phosphorylation, mitochondrial dynamics, oxidant generation, cell death regulation, Ca2+ homeostasis, and proteostasis are involved in these disorders. (AU)

• Processo FAPESP: 17/14713-0 - Ca2+ Mitocondrial no Sistema Nervoso Central e Regulação do Metabolismo Energético
• Beneficiário: João Victor Cabral Costa
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs