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Camacho, Mariana R.
[1]
;
Etchebehere, Elba
[2, 1]
;
Tardelli, Natalia
[3]
;
Delamain, Marcia T.
[4]
;
Vercosa, Aline F. A.
[2]
;
Takahashi, Maria E. S.
[5]
;
Brunetto, Sergio Q.
[6]
;
Metze, Irene G. H. L.
[3, 4]
;
Souza, Carmino A.
[3, 4]
;
Cerci, Juliano J.
[7]
;
Ramos, Celso D.
[3, 2, 1]
Número total de Autores: 11
|
| Afiliação do(s) autor(es): | [1] MND Campinas, Campinas - Brazil
[2] Univ Estadual Campinas, Dept Radiol, Div Nucl Med, Rua Roxo Moreira S-N, POB 6142, BR-13083970 Campinas - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Campinas - Brazil
[4] Univ Estadual Campinas, Dept Internal Med, Div Hematol & Hemotherapy, Campinas - Brazil
[5] Univ Estadual Campinas, Inst Phys, Campinas - Brazil
[6] Univ Estadual Campinas, Biomed Engn Ctr, Campinas - Brazil
[7] Quanta Diag & Therapy Clin, Curitiba, Parana - Brazil
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY; v. 48, n. 1, p. 30-35, MAR 1 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Quantification of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) can be time-consuming. We evaluated the performance of an automatic multifocal segmentation (MFS) method of quantification in patients with different stages of Hodgkin lymphoma, using the multiple VOI (MV) method as reference. Methods: This prospective bicentric study included 50 patients with Hodgkin lymphoma who underwent staging F-18-FGD PET/CT. The examinations were centrally reviewed and processed with commercial MFS software to obtain MTV and TLG using 2 fixed relative thresholds (40% and 20% of SUV max ) for each lesion. All PET/CT scans were processed using the MV and MFS methods. Interclass correlation coefficients and Bland-Altman plots were used for statistical analysis. Repeated calculations of MW and TLG values by 2 observers with different degrees of PET/CT imaging experience were used to ascertain interobserver agreement on the MFS method. Results: The means and SDs obtained for the MW with MV and MFS were, respectively, 736 +/- 856 mL and 660 +/- 699 mL for the 20% threshold and 313 +/- 359 mL and 372 +/- 434 mL for the 40% threshold. The time spent calculating the MW was much shorter with the MFS method than with the MV method (median time, 11.6 min {[}range, 1-30 min] and 64.4 min {[}range, 1-240 min], respectively), especially in patients with advanced disease. Time spent was similar in patients with localized disease. There were no statistical differences between the MFS values obtained by the 2 different observers. Conclusion: MTV and TLG calculations using MFS are reproducible, generate similar results to those obtained with MV, and are much less timing-consuming. Main differences between the 2 methods were related to difficulties in avoiding overlay of VOIs in the MV technique. MV and MFS perform equally well in patients with a small number of lesions. (AU) | |
| Processo FAPESP: | 18/00654-4 - ESTUDO PILOTO DE COMPARAÇÃO ENTRE NEOVASCULARIZAÇÃO E HIPERMETABOLISMO CELULAR NO MIELOMA MÚLTIPLO UTILIZANDO IMAGENS DE PET/CT PSMA-68Ga E PET/CT FDG-18F |
| Beneficiário: | Celso Darío Ramos |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 09/54065-0 - EMU: aquisição de PET/CT para quantificação da atividade metabólica de tecidos vivos |
| Beneficiário: | Carmino Antonio de Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |