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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Validation of a Multifocal Segmentation Method for Measuring Metabolic Tumor Volume in Hodgkin Lymphoma

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Author(s):
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Camacho, Mariana R. [1] ; Etchebehere, Elba [2, 1] ; Tardelli, Natalia [3] ; Delamain, Marcia T. [4] ; Vercosa, Aline F. A. [2] ; Takahashi, Maria E. S. [5] ; Brunetto, Sergio Q. [6] ; Metze, Irene G. H. L. [3, 4] ; Souza, Carmino A. [3, 4] ; Cerci, Juliano J. [7] ; Ramos, Celso D. [3, 2, 1]
Total Authors: 11
Affiliation:
[1] MND Campinas, Campinas - Brazil
[2] Univ Estadual Campinas, Dept Radiol, Div Nucl Med, Rua Roxo Moreira S-N, POB 6142, BR-13083970 Campinas - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Campinas - Brazil
[4] Univ Estadual Campinas, Dept Internal Med, Div Hematol & Hemotherapy, Campinas - Brazil
[5] Univ Estadual Campinas, Inst Phys, Campinas - Brazil
[6] Univ Estadual Campinas, Biomed Engn Ctr, Campinas - Brazil
[7] Quanta Diag & Therapy Clin, Curitiba, Parana - Brazil
Total Affiliations: 7
Document type: Journal article
Source: JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY; v. 48, n. 1, p. 30-35, MAR 1 2020.
Web of Science Citations: 0
Abstract

Quantification of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) can be time-consuming. We evaluated the performance of an automatic multifocal segmentation (MFS) method of quantification in patients with different stages of Hodgkin lymphoma, using the multiple VOI (MV) method as reference. Methods: This prospective bicentric study included 50 patients with Hodgkin lymphoma who underwent staging F-18-FGD PET/CT. The examinations were centrally reviewed and processed with commercial MFS software to obtain MTV and TLG using 2 fixed relative thresholds (40% and 20% of SUV max ) for each lesion. All PET/CT scans were processed using the MV and MFS methods. Interclass correlation coefficients and Bland-Altman plots were used for statistical analysis. Repeated calculations of MW and TLG values by 2 observers with different degrees of PET/CT imaging experience were used to ascertain interobserver agreement on the MFS method. Results: The means and SDs obtained for the MW with MV and MFS were, respectively, 736 +/- 856 mL and 660 +/- 699 mL for the 20% threshold and 313 +/- 359 mL and 372 +/- 434 mL for the 40% threshold. The time spent calculating the MW was much shorter with the MFS method than with the MV method (median time, 11.6 min {[}range, 1-30 min] and 64.4 min {[}range, 1-240 min], respectively), especially in patients with advanced disease. Time spent was similar in patients with localized disease. There were no statistical differences between the MFS values obtained by the 2 different observers. Conclusion: MTV and TLG calculations using MFS are reproducible, generate similar results to those obtained with MV, and are much less timing-consuming. Main differences between the 2 methods were related to difficulties in avoiding overlay of VOIs in the MV technique. MV and MFS perform equally well in patients with a small number of lesions. (AU)

FAPESP's process: 18/00654-4 - Comparison between Neovascularization and Cellular Hypermetabolism in Multiple Myeloma Using 68Ga-PSMA and 18F-FDG PET/CT Imaging - A Pilot Study
Grantee:Celso Darío Ramos
Support type: Regular Research Grants
FAPESP's process: 09/54065-0 - Acquisition of a PET/CT for the quantification of metabolic activity in living tissue
Grantee:Carmino Antonio de Souza
Support type: Multi-user Equipment Program