Validation of a Multifocal Segmentation Method for Measuring Metabolic Tumor Volume in Hodgkin Lymphoma

Autor(es):Mostrar menos -

Camacho, Mariana R. ^[1] ; Etchebehere, Elba ^{[2, 1]} ; Tardelli, Natalia ^[3] ; Delamain, Marcia T. ^[4] ; Vercosa, Aline F. A. ^[2] ; Takahashi, Maria E. S. ^[5] ; Brunetto, Sergio Q. ^[6] ; Metze, Irene G. H. L. ^{[3, 4]} ; Souza, Carmino A. ^{[3, 4]} ; Cerci, Juliano J. ^[7] ; Ramos, Celso D. ^{[3, 2, 1]}

Afiliação do(s) autor(es)

^[1] MND Campinas, Campinas - Brazil

^[2] Univ Estadual Campinas, Dept Radiol, Div Nucl Med, Rua Roxo Moreira S-N, POB 6142, BR-13083970 Campinas - Brazil

^[3] Univ Estadual Campinas, Sch Med Sci, Campinas - Brazil

^[4] Univ Estadual Campinas, Dept Internal Med, Div Hematol & Hemotherapy, Campinas - Brazil

^[5] Univ Estadual Campinas, Inst Phys, Campinas - Brazil

^[6] Univ Estadual Campinas, Biomed Engn Ctr, Campinas - Brazil

^[7] Quanta Diag & Therapy Clin, Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY; v. 48, n. 1, p. 30-35, MAR 1 2020.
• Citações Web of Science: 0

Resumo

Quantification of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) can be time-consuming. We evaluated the performance of an automatic multifocal segmentation (MFS) method of quantification in patients with different stages of Hodgkin lymphoma, using the multiple VOI (MV) method as reference. Methods: This prospective bicentric study included 50 patients with Hodgkin lymphoma who underwent staging F-18-FGD PET/CT. The examinations were centrally reviewed and processed with commercial MFS software to obtain MTV and TLG using 2 fixed relative thresholds (40% and 20% of SUV max ) for each lesion. All PET/CT scans were processed using the MV and MFS methods. Interclass correlation coefficients and Bland-Altman plots were used for statistical analysis. Repeated calculations of MW and TLG values by 2 observers with different degrees of PET/CT imaging experience were used to ascertain interobserver agreement on the MFS method. Results: The means and SDs obtained for the MW with MV and MFS were, respectively, 736 +/- 856 mL and 660 +/- 699 mL for the 20% threshold and 313 +/- 359 mL and 372 +/- 434 mL for the 40% threshold. The time spent calculating the MW was much shorter with the MFS method than with the MV method (median time, 11.6 min {[}range, 1-30 min] and 64.4 min {[}range, 1-240 min], respectively), especially in patients with advanced disease. Time spent was similar in patients with localized disease. There were no statistical differences between the MFS values obtained by the 2 different observers. Conclusion: MTV and TLG calculations using MFS are reproducible, generate similar results to those obtained with MV, and are much less timing-consuming. Main differences between the 2 methods were related to difficulties in avoiding overlay of VOIs in the MV technique. MV and MFS perform equally well in patients with a small number of lesions. (AU)

• Processo FAPESP: 18/00654-4 - ESTUDO PILOTO DE COMPARAÇÃO ENTRE NEOVASCULARIZAÇÃO E HIPERMETABOLISMO CELULAR NO MIELOMA MÚLTIPLO UTILIZANDO IMAGENS DE PET/CT PSMA-68Ga E PET/CT FDG-18F
• Beneficiário: Celso Darío Ramos
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/54065-0 - EMU: aquisição de PET/CT para quantificação da atividade metabólica de tecidos vivos
• Beneficiário: Carmino Antonio de Souza
• Linha de fomento: Auxílio à Pesquisa - Programa Equipamentos Multiusuários