Photobiomodulation effect on local hemoglobin concentration assessed by near-infrared spectroscopy in humans

Autor(es)

Linares, Stephanie Nogueira ^[1] ; Beltrame, Thomas ^{[2, 1]} ; Ferraresi, Cleber ^[3] ; Galdino, Gabriela Aguiar Mesquita ^[1] ; Catai, Aparecida Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Cardiovasc Phys Therapy Lab, Dept Phys Therapy, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Inst Comp, Sao Paulo - Brazil

^[3] Univ Brasil, Biomed Engn Postgrad Program, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Medical Science; v. 35, n. 3, p. 641-649, APR 2020.
• Citações Web of Science: 1

Resumo

Exposure of biological tissue to photobiomodulation therapy (PBMT) seems to increase the oxygen availability and mitochondrial electrochemical activity. With the advancement of new technologies, such as near-infrared spectroscopy (NIRS), information can be obtained about the balance between oxygen utilization and delivery by assessing local oxy- ({[}O(2)Hb]) and deoxy-myohemoglobin ({[}HHb]) concentrations, both measured in micromolars (mu M). Consequently, NIRS can be used to study ({''}in vivo{''}) PBMT effects on the oxidative system, including oxygen availability. Thus, the main objective of the present study was to use NIRS to investigate the acute effects of PBMT by light-emitting diode (LED) on the oxygen delivery and utilization in humans. Twelve healthy young participants were treated with a LED device (850 nm, 50 mW, 2 J) and placebo applied over the proximal third of the flexor carpi ulnaris muscle of the left or right forearm selected in a random order. The LED was applied in direct contact with skin and the device was switched on for 40 s in 4 different interventions (I-1, I-2, I-3 and I-4) with a 3-min interval between interventions. The placebo condition was considered as the period before the first PBMT. The NIRS device was used to evaluate the relative changes in {[}O(2)Hb] and {[}HHb] before and after placebo and interventions. We found that PBMT statistically increased the {[}O(2)Hb] in 0.39 mu M. These results demonstrate the potential of PBMT to increase oxygen availability. (AU)

• Processo FAPESP: 17/09639-5 - Explorando técnicas de aprendizado de máquina para a modelagem do sistema aeróbio e suas aplicações em programas de reabilitação cardiorrespiratória
• Beneficiário: Thomas Beltrame
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07953-3 - Avaliação do efeito agudo da fototerapia por meio de diodos emissores de luz (LEDs) na cinética do consumo de oxigênio muscular e pulmonar em pacientes com diabetes mellitus
• Beneficiário: Aparecida Maria Catai
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/19016-8 - Associações entre aptidão e potência aeróbia
• Beneficiário: Thomas Beltrame
• Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado