| Texto completo | |
| Autor(es): Mostrar menos - |
Veiga, Amanda C.
[1]
;
Milanez, Maycon I. O.
[1]
;
Ferreira, Giovanna R.
[1]
;
Lopes, Nathalia R.
[1]
;
Santos, Camila P.
[1]
;
De Angelis, Katia
[1]
;
Garcia, Michelle L.
[1]
;
Oyama, Lila M.
[1]
;
Gomes, Guiomar N.
[1]
;
Nogueira, Fernando N.
[2]
;
Carvalho, Polliane M.
[2]
;
Campos, Ruy R.
[1]
;
Bergamaschi, Cassia T.
[1]
;
Nishi, Erika E.
[1]
Número total de Autores: 14
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dent Fac, Dept Biomat & Oral Biol, Sao Paulo - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Hypertension; v. 38, n. 4, p. 765-773, APR 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Background: Clinical and experimental evidence have shown that renal denervation, by removing both the sympathetic and afferent nerves, improves arterial hypertension and renal function in chronic kidney disease (CKD). Given the key role of renal sympathetic innervation in maintaining sodium and water homeostasis, studies have indicated that the total removal of renal nerves leads to impaired compensatory mechanisms during hemodynamic challenges. Method: In the present study, we hypothesized that afferent (or sensory) fibers from the diseased kidney contribute to sympathetic overactivation to the kidney and other target organ, such as the splanchnic region, contributing to hypertension in CKD. We used a method to remove selectively the afferent renal fibers (periaxonal application of 33 mmol/l capsaicin) in a rat model of CKD, the 5/6 nephrectomy. Results: Three weeks after afferent renal denervation (ARD), we found a decrease in mean arterial pressure (similar to 15%) and normalization in renal and splanchnic sympathetic nerve hyperactivity in the CKD group. Interestingly, intrarenal renin--angiotensin system, as well as renal fibrosis and function and proteinuria were improved after ARD in CKD rats. Conclusion: The findings demonstrate that afferent fibers contribute to the maintenance of arterial hypertension and reduced renal function that are likely to be mediated by increased sympathetic nerve activity to the renal territory as well as to other target organs in CKD. (AU) | |
| Processo FAPESP: | 18/02671-3 - Ações funcionais e moleculares do nervo renal na doença renal crônica experimental |
| Beneficiário: | Cassia Marta de Toledo Bergamaschi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/23741-6 - Avaliação dos mecanismos centrais do reflexo reno-renal e o papel dos nervos aferentes renais na hipertensão renovascular |
| Beneficiário: | Erika Emy Nishi |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 17/03905-5 - Avaliação da influência da inervação aferente renal na insuficiência renal crônica experimental |
| Beneficiário: | Amanda Costa Veiga |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |