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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Anti-inflammatory and anti-Candida Effects of Brazilian Organic Propolis, a Promising Source of Bioactive Molecules and Functional Food

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Autor(es):
Nani, Bruno Dias [1] ; Orlandi Sardi, Janaina de Cassia [1] ; Lazarini, Josy Goldoni [1] ; Silva, Diego Romario [1] ; Massariolli, Adna Prado [2] ; Cunha, Thiago Mattar [3] ; de Alencar, Severino Matias [2] ; Franchin, Marcelo [1] ; Rosalen, Pedro Luiz [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, BR-13414018 Piracicaba, SP - Brazil
[2] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Agrifood Ind Food & Nutr, BR-13418900 Piracicaba, SP - Brazil
[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Journal of Agricultural and Food Chemistry; v. 68, n. 10, p. 2861-2871, MAR 11 2020.
Citações Web of Science: 0
Resumo

Brazilian organic propolis (BOP) is an unexplored Brazilian propolis that is produced organically and certified according to international legislation. Our results showed that BOP has strong anti-inflammatory effects and acts by reducing nuclear factor kappa B activation, tumor necrosis factor a release, and neutrophil migration. In addition, BOP6 exhibited antifungal activity on planktonic and biofilm cultures of Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, and Candida parapsisolis and reduced in vitro yeast cell adhesion to human keratinocytes at sub-inhibitory concentrations. BOP demonstrated significantly low toxicity in Galleria melonella larvae at antifungal doses. Lastly, a chemical analysis revealed the presence of caffeoyltartaric acid, 3,4-dicaffeoylquinic acid, quercetin, and gibberellins A7, A9, and A20, which may be responsible for the biological properties observed. Thus, our data indicate that BOP is a promising source of anti-inflammatory and antifungal molecules that may be used as a functional food. (AU)

Processo FAPESP: 17/09898-0 - Bioprospecção de novas moléculas anti-inflamatórias de produtos naturais nativos brasileiros
Beneficiário:Pedro Luiz Rosalen
Linha de fomento: Auxílio à Pesquisa - Regular