Osteoporosis evaluation through full developed speckle imaging

Autor(es)

Amaral, Marcello Magri ^[1] ; del-Valle, Matheus ^{[2, 3]} ; Raele, Marcus Paulo ^[2] ; De Pretto, Lucas Ramos ^[2] ; Ana, Patricia Aparecida ^[3]

Afiliação do(s) autor(es)

^[1] Univ Brazil, Inst Cient & Tecnol, Rua Carolina Fonseca 235, BR-05508000 Sao Paulo - Brazil

^[2] CNEN SP, IPEN, Sao Paulo - Brazil

^[3] Fed Univ ABC, Ctr Engn Modeling & Appl Social Sci, Sao Bernardo Do Campo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Biophotonics; v. 13, n. 7 APR 2020.
• Citações Web of Science: 0

Resumo

Osteoporosis is a disease characterized by bone mineral density reduction, weakening the bone structure. Its diagnosis is performed using ionizing radiation, increasing health risk. Optical techniques are safer, due to non-ionizing radiation use, but limited to the analyses of bone tissue. This limitation may be circumvented in the oral cavity. In this work we explored the use of laser speckle imaging (LSI) to differentiate the sound and osteoporotic maxilla and mandible bones in an in vitro model. Osteoporosis lesions were simulated with acid attack. The samples were evaluated by optical profilometry and LSI, using a custom software. Two image parameters were evaluated, speckle contrast ration and patches ratio. With the speckle contrast ratio, it was possible to differentiate sound from osteoporotic tissue. From speckle patches ratio it was observed a negative correlation with the roughness parameter. LSI is a promissory technique for assessment of osteoporosis lesions on alveolar bone. (AU)

• Processo FAPESP: 17/21887-4 - Análise e modelagem do comportamento térmico, óptico, e mecânico dos tecidos orais sadios e desmineralizados durante radioterapia submetidos à irradiação laser em alta intensidade de pulsos curtos associados ou não a materiais bioativos
• Beneficiário: Patricia Aparecida da Ana
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/21851-0 - Desenvolvimento de metodologias de análise de imagens e sinais de tomografia por coerência óptica (OCT) para avaliação de angiogênese cutânea
• Beneficiário: Marcello Magri Amaral
• Modalidade de apoio: Auxílio à Pesquisa - Regular