Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review

Autor(es)

Santos, Soraya Silva ^[1] ; de Araujo, Renan Vinicius ^[1] ; Giarolla, Jeanine ^[1] ; El Seoud, Omar ^[1] ; Ferreira, Elizabeth Igne ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Lab Design & Synth Chemotherapeut Potentially Act, Ave Prof Lineu Prestes, 580 Bldg 13, BR-05508900 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS; v. 55, n. 4 APR 2020.
• Citações Web of Science: 0

Resumo

Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are a considerable global challenge. Despite the huge number of people infected, NDs do not create interest from pharmaceutical companies because the associated revenue is generally low. Most of the research on these diseases has been conducted in academic institutions. The chemotherapeutic armamentarium for NDs is scarce and inefficient and better drugs are needed. Researchers have found some promising potential drug candidates using medicinal chemistry and computational approaches. Most of these compounds are synthetic but some are from natural sources or are semi-synthetic. Drug repurposing or repositioning has also been greatly stimulated for NDs. This review considers some potential drug candidates and provides details of their design, discovery and activity. (C) 2020 Published by Elsevier B.V. (AU)

• Processo FAPESP: 15/19438-1 - Síntese e estudos de liberação de compostos bioativos a partir de pró-fármacos e fármacos dirigidos dendriméricos potencialmente ativos em doenças negligenciadas
• Beneficiário: Jeanine Giarolla Vargas
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/21154-7 - Dendrímero de poliamidoamina (PAMAM) de primeira geração: planejamento e síntese de pró-fármaco potencialmente ativo em tuberculose
• Beneficiário: Renan Vinicius de Araujo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica