Morphology, Volume, and Density Characteristics of the Parotid Glands before and after Chemoradiation Therapy in Patients with Head and Neck Tumors

Autor(es)

Santos, Wellington Pereira dos ^[1] ; Gomes, Joao Pedro Perez ^[2] ; Nussi, Amanda Drumstas ^[3] ; Altemani, Joao Mauricio ^[4] ; dos Santos, Maria Teresa Botti Rodrigues ^[3] ; Hasseus, Bengt ^[5] ; Giglio, Daniel ^[6] ; Braz-Silva, Paulo Henrique ^{[2, 7]} ; Costa, Andre Luiz Ferreira ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Fac Med Sci, Campinas, SP - Brazil

^[2] Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo, SP - Brazil

^[3] Cruzeiro Univ UNICSUL, Postgrad Program Dent, Sao Paulo, SP - Brazil

^[4] Univ Campinas UNICAMP, Dept Radiol, Fac Med Sci, Campinas, SP - Brazil

^[5] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, Gothenburg - Sweden

^[6] Univ Gothenburg, Inst Clin Sci, Dept Oncol, Sahlgrenska Acad, Gothenburg - Sweden

^[7] Univ Sao Paulo, Sch Med, Inst Trop Med Sao Paulo, Lab Virol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF DENTISTRY; v. 2020, MAR 26 2020.
• Citações Web of Science: 0

Resumo

The multimodal approach for patients with head and neck cancer (HNC) includes treatment with chemoradiation therapy (CRT). A common concern regarding CRT side effects is the occurrence of structural and physiological alterations of the salivary glands due to exposure to ionizing radiation. The aim of this study is to examine the morphology, volume, and density of the parotid glands before and after CRT in HNC patients. A total of 49 HNC patients treated exclusively with CRT were included in the study. Ninety-eight parotid glands were evaluated before and after treatment by using contrast-enhanced computed tomography (CECT). Shapiro-Wilk test was performed, and the variables (pre-CRT and post-CRT) presented normal distribution. Pearson's coefficient was used to assess the correlation between volume and density. CRT resulted in a significant decrease in the mean volume of the parotid glands (i.e., original volume reduced by 20.5%; P<0.0001). CRT induced a 30.0% (7 Hounsfield units) increase in density of the right parotid gland and a 24.9% (8 Hounsfield units) increase in density of the left parotid gland (P=0.0198 and P=0.0079, respectively). Changes in morphology and spatial configuration, increased density, and substantial loss of volume of the parotid glands were observed after CRT. There was also a difference in density (P=0.003) in the right-side parotid glands in comparison between xerostomic and nonxerostomic groups of patients. These facts lead to the need for a personalized CRT planning in order to minimize oral complications related to the treatment. (AU)

• Processo FAPESP: 17/09550-4 - Análise de textura em imagens de ressonância magnética como ferramenta de auxílio na caracterização e classificação de ameloblastomas e queratocistos
• Beneficiário: André Luiz Ferreira Costa
• Modalidade de apoio: Auxílio à Pesquisa - Regular