Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies

Autor(es):Mostrar menos -

Jorge, Ludmilla R. ^[1] ; Harada, Liliam K. ^[1] ; Silva, Erica C. ^[1] ; Campos, Welida F. ^[1] ; Morelli, Fernanda C. ^[1] ; Shimamoto, Gustavo ^[2] ; Pereira, Jorge F. B. ^[3] ; Oliveira Jr, Jose M. ; Tubino, Matthieu ^[2] ; Vila, Marta M. D. C. ^[4] ; Balcao, Victor M. ^{[5, 6, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sorocaba, Lab Biofilms & Bacteriophages, PhageLab, Sorocaba - Brazil

^[2] Univ Estadual Campinas, Inst Chem, Campinas - Brazil

^[3] Univ Coimbra, CIEPOPF Dept Chem Engn, Coimbra - Portugal

^[4] Oliveira Jr, Jr., Jose M., Univ Sorocaba, Lab Biofilms & Bacteriophages, PhageLab, Sorocaba - Brazil

^[5] Univ Aveiro, Dept Biol, Aveiro - Portugal

^[6] Univ Aveiro, CESAM, Aveiro - Portugal

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PHARMACOLOGY; v. 11, APR 23 2020.
• Citações Web of Science: 0

Resumo

In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (H-1 NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin. (AU)

• Processo FAPESP: 16/08884-3 - PneumoPhageColor - desenvolvimento de um kit de biodetecção colorimétrica de Pseudomonas aeruginosa com base em partículas fágicas
• Beneficiário: Vitor Manuel Cardoso Figueiredo Balcão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/05522-9 - PsaPhageKill - isolamento, caracterização e uso de bacteriófagos líticos contra Pseudomonas syringae pv. actinidiae para combater o cancro do kiwi: uma alternativa eficiente e amiga do ambiente
• Beneficiário: Vitor Manuel Cardoso Figueiredo Balcão
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 16/12234-4 - TransAppIL - Permeação cutânea de entidades proteicas estabilizadas estruturalmente e funcionalmente, carreadas por líquidos iônicos.
• Beneficiário: Marta Maria Duarte Carvalho Vila
• Modalidade de apoio: Auxílio à Pesquisa - Regular