Aglycone-rich extracts from citrus by-products induced endothelium -independent relaxation in isolated arteries

Autor(es)

Ruviaro, Amanda Roggia ^[1] ; Menezes Barbosa, Paula de Paula ^[2] ; Alexandre, Eduardo Costa ^[3] ; Oliveira Justo, Alberto Fernando ^[3] ; Antunes, Edson ^[3] ; Macedo, Gabriela Alves ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Fac Food Engn, Dept Food & Nutr, Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Fac Food Engn, Dept Food Biochem, Campinas, SP - Brazil

^[3] Univ Campinas UNICAMP, Dept Pharmacol, Fac Med Sci, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY; v. 23, JAN 2020.
• Citações Web of Science: 0

Resumo

Citrus by-products are rich in flavanone aglycons which have lower bioactivity than aglycone forms. Based on this, the study evaluated the effects of enzyme biotransformation on antioxidant and vasorelaxant capacity of polyphenolic rich-extracts from citrus waste. Enzymatic treatment produced extracts with high hesperetin concentrations and higher antioxidant capacity than non-treated extracts. At the highest concentration tested (3 mg mL(-1)), citrus juice by-products exhibited only a partial vasorelaxant effect. After the enzymatic treatment, the extract had a maximal effect of 100% relaxation and enhanced their pEC(50). The relaxation promoted by citrus pectin by-products was potentiated in the presence of ODQ, suggesting that vasorelaxant effects of these extracts may occur even when sGC is oxidized because of vascular oxidative stress. Thus, the enzyme-assisted extraction appears to enhance antioxidant and vasorelaxant properties of citrus extracts, which could be used to develop new products with antihypertensive properties. (AU)

• Processo FAPESP: 15/04555-2 - Desenvolvimento de processos biológicos para obtenção de extratos ricos em compostos fenólicos a partir de resíduos da indústria de cítricos e avaliação do potencial bioativo dos extratos
• Beneficiário: Gabriela Alves Macedo
• Modalidade de apoio: Auxílio à Pesquisa - Regular