| Texto completo | |
| Autor(es): |
Pazin, Wallance M.
[1, 2]
;
Furini, Leonardo N.
[3, 1]
;
Solovyeva, Vita
[2, 4]
;
Lemma, Tibebe
[1]
;
Rubira, Rafael J. G.
[1]
;
Jorgensen, Bjarke
[5]
;
Constantino, Carlos J. L.
[1]
;
Brewer, Jonathan R.
[2]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Sao Paulo State Univ, Sch Technol & Appl Sci, Dept Phys, Presidente Prudente - Brazil
[2] Univ Southern Denmark, Dept Biochem & Mol Biol BMB, Odense - Denmark
[3] Univ Fed Ceara, Dept Phys, Fortaleza, Ceara - Brazil
[4] Carl von Ossietzky Univ Oldenburg, Fac Math & Sci, Oldenburg - Germany
[5] Newtec Engn AS, Odense - Denmark
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Applied Spectroscopy; v. 74, n. 7 APR 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
In the following work, the vibrational spectroscopic characteristics of artepillin C are reported by means of Fourier transform infrared (FT-IR) and Raman spectroscopies, surface-enhanced Raman scattering (SERS), and coherent anti-Stokes Raman scattering (CARS) microscopy. Artepillin C is an interesting compound due to its pharmacological properties, including antitumor activity. It is found as the major component of Brazilian green propolis, a resinous mixture produced by bees to protect their hives against intruders. Vibrational spectroscopic techniques have shown a strong peak at 1599 cm(-1), assigned to C=C stretching vibrations from the aromatic ring of artepillin C. From these data, direct visualization of artepillin C could be assessed by means of CARS microscopy, showing differences in the film hydration obtained for its neutral and deprotonated states. Raman-based methods show potential to visualize the uptake and action of artepillin C in biological systems, triggering its interaction with biological systems that are needed to understand its mechanism of action. (AU) | |
| Processo FAPESP: | 16/09633-4 - Mecanismo de ação do composto bioativo Artepillin C em sistemas miméticos de membranas e membranas citoplasmáticas de células tumorais |
| Beneficiário: | Wallance Moreira Pazin |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 17/23426-4 - Efeitos da interação da Artepillin C com membranas de células tumorais: um estudo por microscopia de fluorescência avançada |
| Beneficiário: | Wallance Moreira Pazin |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |