Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis

Autor(es)

Jesus, Aline A. ^[1] ; Passaglia, Patricia ^[1] ; Santos, Bruna M. ^[1] ; Rodrigues-Santos, Isabelle ^[1] ; Flores, Rafael A. ^[1] ; Batalhao, Marcelo E. ^[2] ; Stabile, Angelita M. ^[2] ; Carnio, Evelin C. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Sch Nursing Ribeirao Preto, Dept Gen & Specialized Nursing, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brain Research; v. 1739, JUL 15 2020.
• Citações Web of Science: 0

Resumo

The central nervous system (CNS) is one of the first physiological systems to be affected in sepsis. During the exacerbated systemic inflammatory response at the early stage of sepsis, circulatory inflammatory mediators are able to reach the CNS leading to neuroinflammation and, consequently, long-term impairment in learning and memory formation is observed. The acute treatment with molecular hydrogen (H-2) exerts important antioxidative, antiapoptotic, and anti-inflammatory effects in sepsis, but little is known about the mechanism itself and the efficacy of chronic H-2 inhalation in sepsis treatment. Thus, we tested two hypotheses. We first hypothesized that chronic H-2 inhalation is also an effective therapy to treat memory impairment induced by sepsis. The second hypothesis is that H-2 treatment decreases sepsis-induced neuroinflammation in the hippocampus and prefrontal cortex, important areas related to short and long-term memory processing. Our results indicate that (1) chronic exposure of hydrogen gas is a simple, safe and promising therapeutic strategy to prevent memory loss in patients with sepsis and (2) acute H-2 inhalation decreases neuroinflammation in memory-related areas and increases total nuclear factor E2-related factor 2 (Nrf2), a transcription factor that regulates a vast group of antioxidant and inflammatory agents expression in these areas of septic animals. (AU)

• Processo FAPESP: 18/18459-3 - Alterações fisiopatológicas durante a inflamação sistêmica
• Beneficiário: Aline Alves de Jesus
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 16/09364-3 - Papel do sulfeto de hidrogênio endógeno na área preóptica modulando a tolerância ao LPS.
• Beneficiário: Bruna Maitan Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/22477-6 - Participação da angiotensina-(1-7) na regulação da síntese e liberação de vasopressina durante a endotoxemia
• Beneficiário: Patrícia Passaglia
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 15/09857-7 - Ação central de angiotensina (1-7) sobre a liberação de vasopressina durante o choque endotoxêmico.
• Beneficiário: Evelin Capellari Cárnio
• Modalidade de apoio: Auxílio à Pesquisa - Regular