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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis

Full text
Author(s):
Jesus, Aline A. [1] ; Passaglia, Patricia [1] ; Santos, Bruna M. [1] ; Rodrigues-Santos, Isabelle [1] ; Flores, Rafael A. [1] ; Batalhao, Marcelo E. [2] ; Stabile, Angelita M. [2] ; Carnio, Evelin C. [1, 2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Sch Nursing Ribeirao Preto, Dept Gen & Specialized Nursing, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Brain Research; v. 1739, JUL 15 2020.
Web of Science Citations: 0
Abstract

The central nervous system (CNS) is one of the first physiological systems to be affected in sepsis. During the exacerbated systemic inflammatory response at the early stage of sepsis, circulatory inflammatory mediators are able to reach the CNS leading to neuroinflammation and, consequently, long-term impairment in learning and memory formation is observed. The acute treatment with molecular hydrogen (H-2) exerts important antioxidative, antiapoptotic, and anti-inflammatory effects in sepsis, but little is known about the mechanism itself and the efficacy of chronic H-2 inhalation in sepsis treatment. Thus, we tested two hypotheses. We first hypothesized that chronic H-2 inhalation is also an effective therapy to treat memory impairment induced by sepsis. The second hypothesis is that H-2 treatment decreases sepsis-induced neuroinflammation in the hippocampus and prefrontal cortex, important areas related to short and long-term memory processing. Our results indicate that (1) chronic exposure of hydrogen gas is a simple, safe and promising therapeutic strategy to prevent memory loss in patients with sepsis and (2) acute H-2 inhalation decreases neuroinflammation in memory-related areas and increases total nuclear factor E2-related factor 2 (Nrf2), a transcription factor that regulates a vast group of antioxidant and inflammatory agents expression in these areas of septic animals. (AU)

FAPESP's process: 18/18459-3 - Physiopathological changes during systemic inflammation
Grantee:Aline Alves de Jesus
Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
FAPESP's process: 16/09364-3 - Role of endogenous preoptic hydrogen sulfide modulating LPS tolerance.
Grantee:Bruna Maitan Santos
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/22477-6 - Participation of angiotensin-(1-7) in the regulation of synthesis and release of vasopressin during endotoxemia
Grantee:Patrícia Passaglia
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/09857-7 - Central effect of angiotensin (1-7) on the vasopressin release during endotoxemic shock.
Grantee:Evelin Capellari Cárnio
Support Opportunities: Regular Research Grants