Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling-an update

Autor(es)

Ratajczak, Mariusz Z. ^{[1, 2]} ; Adamiak, Mateusz ^[2] ; Bujko, Kamila ^[1] ; Thapa, Arjun ^[1] ; Pensato, Valentina ^[1] ; Kucia, Magda ^{[1, 2]} ; Ratajczak, Janina ^[1] ; Ulrich, Henning ^[3]

Afiliação do(s) autor(es)

^[1] Univ Louisville, Stem Cell Inst, James Graham Brown Canc Ctr, 500 S Floyd St, Rm 107, Louisville, KY 40202 - USA

^[2] Univ Warsaw, Ctr Preclin Studies & Technol, Dept Regenerat Med Med, Warsaw - Poland

^[3] Univ Sao Paulo, Inst Chem, Dept Biochem, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PURINERGIC SIGNALLING; MAY 2020.
• Citações Web of Science: 0

Resumo

Bone marrow (BM) as an active hematopoietic organ is highly sensitive to changes in body microenvironments and responds to external physical stimuli from the surrounding environment. In particular, BM tissue responds to several cues related to infections, strenuous exercise, tissue/organ damage, circadian rhythms, and physical challenges such as irradiation. These multiple stimuli affect BM cells to a large degree through a coordinated response of the innate immunity network as an important guardian for maintaining homeostasis of the body. In this review, we will foc++us on the role of purinergic signaling and innate immunity in the trafficking of hematopoietic stem/progenitor cells (HSPCs) during their egression from the BM into peripheral blood (PB), as seen along pharmacological mobilization, and in the process of homing and subsequent engraftment into BM after hematopoietic transplantation. Innate immunity mediates these processes by engaging, in addition to certain peptide-based factors, other important non-peptide mediators, including bioactive phosphosphingolipids and extracellular nucleotides, as the main topic of this review. Elucidation of these mechanisms will allow development of more efficient stem cell mobilization protocols to harvest the required number of HSPCs for transplantation and to accelerate hematopoietic reconstitution in transplanted patients. (AU)

• Processo FAPESP: 18/07366-4 - Receptores de purinas e cininas como alvos de estudo e intervenção terapêutica em doenças neurológicas
• Beneficiário: Alexander Henning Ulrich
• Modalidade de apoio: Auxílio à Pesquisa - Temático