Harvesting greenish blue luminescence in gold(i) complexes and their application as promising bioactive molecules and cellular bioimaging agents

Autor(es):Mostrar menos -

Favarin, V, Lis R. ; Laranjeira, G. B. ^[1] ; Teixeira, Cristiane F. A. ^[1] ; Silva, Heveline ^[2] ; Micheletti, A. C. ^[1] ; Pizzuti, Lucas ^[1] ; Machulek Junior, Amilcar ^[1] ; Caires, Anderson R. L. ^[1] ; Deflon, Victor M. ^[3] ; Pesci, Rafaela B. P. ^[4] ; Lima Rocha, C. N. ^[5] ; Correa, J. R. ^[5] ; Pinto, L. M. C. ^[1] ; Casagrande, Gleison Antonio ^[1]

Afiliação do(s) autor(es)

^[1] Favarin, Lis R., V, Univ Fed Mato Grosso do Sul, Grp Pesquisa Sintese & Caracterizacao Mol Mato Gr, Inst Quim, Lab 2, Av Senador Filinto Muller 1555, BR-79074460 Campo Grande, MS - Brazil

^[2] Univ Fed Minas Gerais, ICEx, Dept Quim, BR-31270901 Belo Horizonte, MG - Brazil

^[3] Univ Sao Paulo, Inst Quim Sao Carlos, Av Trabalhador Sao Carlense, BR-13566590 Sao Carlos, SP - Brazil

^[4] Univ Fed Paraiba UFPB, Dept Quim, BR-58051900 Joao Pessoa, Paraiba - Brazil

^[5] Univ Brasilia, Lab Microscopia & Microanal, Grp Quimioterap & Sondas Fluorescentes, Inst Ciencias Biol, Av L3 Norte S-N, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEW JOURNAL OF CHEMISTRY; v. 44, n. 17, p. 6862-6871, MAY 7 2020.
• Citações Web of Science: 1

Resumo

Three novel highly photoluminescent mononuclear Au-I compounds (1, 2, and 3) based on mixed phosphine/thiocarbamoyl-pyrazoline materials were synthesized at good yields using a sonochemical method and then structurally characterized. X-ray diffraction studies revealed the compounds to be mononuclear cationic complexes of the {[}Ph3PAu(L)]PF6 type with linear coordination geometry around Au-I atoms. Investigation of photophysical properties showed an intense greenish blue emission when the complexes were excited at 305 nm in solution. The emission was attributed to mixed MLCT + IL and LLCT electronic transitions taking place after ligand complexation, as shown by DFT calculations. Full characterization of the compounds also comprised H-1 and C-13 NMR experiments, elemental analyses, infrared spectroscopy, and absorption-emission studies. Additionally, compounds 1, 2, and 3 and respective ligands were investigated as antibacterial agents against five Streptococcus aureus strains (Gram-positive) and one Escherichia coli strain (Gram-negative) with distinct antibiotic-resistance profiles. Cytotoxic activity was assessed using the MTT method against B16F10 melanoma, 4T1 mammary carcinoma, and normal BHK-21 baby hamster kidney cell lines. The synthesized Au-I compounds proved more active than the respective precursors and free ligands. Tested as probes for cellular bioimaging, the complexes showed good biodistribution in the cytoplasm of MCF-7 and MDA-MB-231 (human breast adenocarcinoma cell lines). (AU)

• Processo FAPESP: 09/54011-8 - EMU: aquisição de difratômetro de raios X de monocristal para análise estrutural de moléculas pequenas e proteínas
• Beneficiário: Victor Marcelo Deflon
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários