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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Harvesting greenish blue luminescence in gold(i) complexes and their application as promising bioactive molecules and cellular bioimaging agents

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Author(s):
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Favarin, V, Lis R. ; Laranjeira, G. B. [1] ; Teixeira, Cristiane F. A. [1] ; Silva, Heveline [2] ; Micheletti, A. C. [1] ; Pizzuti, Lucas [1] ; Machulek Junior, Amilcar [1] ; Caires, Anderson R. L. [1] ; Deflon, Victor M. [3] ; Pesci, Rafaela B. P. [4] ; Lima Rocha, C. N. [5] ; Correa, J. R. [5] ; Pinto, L. M. C. [1] ; Casagrande, Gleison Antonio [1]
Total Authors: 14
Affiliation:
[1] Favarin, Lis R., V, Univ Fed Mato Grosso do Sul, Grp Pesquisa Sintese & Caracterizacao Mol Mato Gr, Inst Quim, Lab 2, Av Senador Filinto Muller 1555, BR-79074460 Campo Grande, MS - Brazil
[2] Univ Fed Minas Gerais, ICEx, Dept Quim, BR-31270901 Belo Horizonte, MG - Brazil
[3] Univ Sao Paulo, Inst Quim Sao Carlos, Av Trabalhador Sao Carlense, BR-13566590 Sao Carlos, SP - Brazil
[4] Univ Fed Paraiba UFPB, Dept Quim, BR-58051900 Joao Pessoa, Paraiba - Brazil
[5] Univ Brasilia, Lab Microscopia & Microanal, Grp Quimioterap & Sondas Fluorescentes, Inst Ciencias Biol, Av L3 Norte S-N, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF - Brazil
Total Affiliations: 5
Document type: Journal article
Source: NEW JOURNAL OF CHEMISTRY; v. 44, n. 17, p. 6862-6871, MAY 7 2020.
Web of Science Citations: 1
Abstract

Three novel highly photoluminescent mononuclear Au-I compounds (1, 2, and 3) based on mixed phosphine/thiocarbamoyl-pyrazoline materials were synthesized at good yields using a sonochemical method and then structurally characterized. X-ray diffraction studies revealed the compounds to be mononuclear cationic complexes of the {[}Ph3PAu(L)]PF6 type with linear coordination geometry around Au-I atoms. Investigation of photophysical properties showed an intense greenish blue emission when the complexes were excited at 305 nm in solution. The emission was attributed to mixed MLCT + IL and LLCT electronic transitions taking place after ligand complexation, as shown by DFT calculations. Full characterization of the compounds also comprised H-1 and C-13 NMR experiments, elemental analyses, infrared spectroscopy, and absorption-emission studies. Additionally, compounds 1, 2, and 3 and respective ligands were investigated as antibacterial agents against five Streptococcus aureus strains (Gram-positive) and one Escherichia coli strain (Gram-negative) with distinct antibiotic-resistance profiles. Cytotoxic activity was assessed using the MTT method against B16F10 melanoma, 4T1 mammary carcinoma, and normal BHK-21 baby hamster kidney cell lines. The synthesized Au-I compounds proved more active than the respective precursors and free ligands. Tested as probes for cellular bioimaging, the complexes showed good biodistribution in the cytoplasm of MCF-7 and MDA-MB-231 (human breast adenocarcinoma cell lines). (AU)

FAPESP's process: 09/54011-8 - Acquisition of a single-crystal X-ray diffractometer for the structural analysis of small molecules and proteins
Grantee:Victor Marcelo Deflon
Support Opportunities: Multi-user Equipment Program