Exploring Nanothermometry in the NIR-II Region and Hyperspectral Bioimaging with Lanthanide-Based Nanomaterials

• Grant number: 24/17123-2
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: February 01, 2025
• End date: January 31, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Rogéria Rocha Gonçalves
• Grantee: York Estewin Serge Correales
• Supervisor: Eva Hemmer
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Institution abroad: University of Ottawa (uOttawa), Canada
• Associated to the scholarship: 23/05351-8 - Development of lanthanide-doped persistent luminescence perovskite oxide nanoparticles for bioimaging and security labeling, BP.PD

Abstract

Luminescent nanoparticles have garnered significant interest for their diverse bioapplications, including disease diagnosis and treatment, nanometer-scale temperature sensing, and cellular bioimaging. Among the various types of nanomaterials explored for such purposes, lanthanide-based nanoparticles (Ln-NPs) stand out due to their unique optical properties, such as the ability to emit light across ultraviolet (UV), visible, and near-infrared (NIR) spectral regions through mechanisms like downshifting, downconversion, and upconversion. Furthermore, the ability of certain lanthanide-based materials to emit light for prolonged periods post-excitation, through phosphorescence or persistent luminescence, enables multifunctional applications in biomedicine. This project will focus on developing Ln-based nanomaterials, specifically perovskite-type oxides (Ba,CaTiO3:RE3+) and rare-earth fluoride nanoparticles (NaYbF4:RE3+@NaYF4), to investigate their potential in NIR nanothermometry and bioimaging based on visible and NIR-II emissions. Furthermore, advanced hyperspectral imaging techniques will be employed to study cellular uptake, localization, and nanoparticle tracking within biological systems, aiming to deepen the understanding of their behavior in complex cellular environments.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE MELO COSTA-SERGE, NAYARA INDORE; DA SILVA, LIVIA ELOY; GRILI, MARIA CAROLINA HEBLING; GONCALVES, ROSEMBERGUE GABRIEL LIMA; CORREALES, YORK ESTEWIN SERGE; PIVA, HENRIQUE LUIS; TEDESCO, ANTONIO CLAUDIO; DE MORAES, LUIZ ALBERTO BERALDO; GONCALVES, ROGERIA ROCHA. Fast degradation of 5-fluorouracil in urban wastewater by peroxymonosulfate activation using MgMnFe-layered double hydroxide. Journal of Materials Science, v. 60, n. 35, p. 17-pg., 2025-09-03. (23/05351-8, 21/11803-3, 23/07220-8, 21/14230-4, 24/16925-8, 20/04009-6, 21/08111-2, 24/21925-7, 24/17123-2)