Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters

Texto completo
Autor(es):
Mostrar menos -
Pott-Junior, Henrique [1] ; Crispim Nascimento, Carla Manuela [2] ; Costa-Guarisco, Leticia Pimenta [2] ; de Oliveira Gomes, Grace Angelica [2] ; Gramani-Say, Karina [2] ; Orlandi, Fabiana de Souza [2] ; Martins Gratao, Aline Cristina [2] ; dos Santos Orlandi, Ariene Angelini [3] ; Iost Pavarini, Sofia Cristina [2] ; Vasilceac, Fernando Augusto [2] ; Zazzetta, Marisa Silvana [2] ; Cominetti, Marcia Regina [2]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Fed Univ Sao Carlos UFSCar, Dept Med, BR-13565905 Sao Carlos - Brazil
[2] Fed Univ Sao Carlos UFSCar, Dept Gerontol, BR-13565905 Sao Carlos - Brazil
[3] Fed Univ Sao Carlos UFSCar, Dept Nursing, BR-13565905 Sao Carlos - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: NUTRIENTS; v. 12, n. 3 MAR 2020.
Citações Web of Science: 0
Resumo

This study investigated the relationship between metabolic parameters and low serum 25-hydroxyvitamin D (25(OH)D) levels in older adults (n = 265). They were assessed for anthropometrics and metabolic measurements, including 25(OH)D, insulin, glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and other inflammatory markers. Vitamin D deficiency was defined as a 25(OH)D level below 50 nmol/L. Comparisons between groups were performed using Wilcoxon-Mann-Whitney or Pearson's Chi-squared test. A multivariate adjusted Poisson regression was used to model the number of metabolic parameters as a function of a set of explanatory variables. Subjects with 25(OH)D deficiency were predominantly females and presented higher body weight, body mass index, waist circumference, triglycerides and Tumor Necrosis Factor-alpha (TNF-alpha), and higher insulin resistance. Metabolic syndrome was also more prevalent among 25(OH)D-deficient subjects. In those without metabolic syndrome, 25(OH)D deficiency was related only to obesity and higher insulin resistance. Female sex, hypertension, higher waist circumference and higher levels of hemoglobin A1C (%), HDL-C, and TG were significantly associated with an increased number of metabolic syndrome parameters after adjusting for covariates, but 25(OH)D was not. The fact that serum 25(OH)D concentration was inversely associated with metabolic syndrome and insulin resistance not only reaffirms the relevance to consider serum 25(OH)D concentration as an influencing factor for insulin resistance, but also the need to actively screen for hypovitaminosis D in all patients with this condition. (AU)

Processo FAPESP: 16/15235-1 - Ferramenta de monitoramento de níveis de fragilidade em idosos atendidos na atenção básica de saúde: avaliação da sua efetividade e eficiência
Beneficiário:Marisa Silvana Zazzetta
Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS
Processo FAPESP: 14/50104-0 - Ferramenta para monitoramento de níveis de fragilidade e fatores associados em idosos atendidos pelo Núcleo de Apoio à Saúde da Família (NASF) no Município de São Carlos
Beneficiário:Marisa Silvana Zazzetta
Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS