Enriched environment and exercise effects on parvalbumin expression and distribution in the hippocampal formation of developing rats

Autor(es)

Serra, Fernando Tadeu ^{[1, 2, 3]} ; Silva Araujo, Bruno Henrique ^[4] ; Diaz Placencia, Eduardo Varejao ^[5] ; Henrique, Jessica Salles ^[1] ; Dona, Flavia ^[6] ; Torres, Laila Brito ^[7] ; da Silva Fernandes, Maria Jose ^[1] ; Arida, Ricardo Mario ^[1] ; da Silva, Swrgio Gomes ^{[2, 8, 3, 9]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Sao Paulo, SP - Brazil

^[2] Univ Mogi das Cruzes UMC, Mogi Das Cruzes, SP - Brazil

^[3] Fac Clube Naut Mogiano FCNM, Mogi Das Cruzes, SP - Brazil

^[4] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, BR-13083970 Campinas, SP - Brazil

^[5] Hosp Israelita Albert Einstein HIAE, Sao Paulo, SP - Brazil

^[6] Univ Anhanguera Sao Paulo UNIAN, Sao Paulo, SP - Brazil

^[7] Univ Sao Paulo, Human Genome & Stem Cell Res Ctr, Biosci Inst, Dept Genet & Evolutionary Biol, Sao Paulo, SP - Brazil

^[8] Ctr Univ UNIFAMINAS, Muriae, MG - Brazil

^[9] Fundacao Cristiano Varella FCV, Hosp Canc Muriae, Muriae, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brain Research Bulletin; v. 160, p. 85-90, JUL 2020.
• Citações Web of Science: 0

Resumo

Several models of environmental enrichment and physical exercise have been used to explore the experience effects on brain functions and plasticity, mainly in adult animals. In order to examine the early influence of these stimuli on developing brain, the present study used calcium-binding protein parvalbumin as neuroplastic marker in the hippocampal formation of male Wistar rats subjected to environmental enrichment or physical exercise from postnatal days 21 to 60 (P21-P60). In our study, no significant difference in hippocampal expression and distribution of parvalbumin was found between enriched and control rats. However, a significant increase in parvalbumin protein expression as well as in the number of neurons stained with parvalbumin was observed in the hippocampal formation of rats submitted to daily treadmill exercise when compared to the control rats. The hippocampal region with the highest number of parvalbumin neurons in exercised rats was Cornus of Amon 2 e 3 (CA2/CA3). These findings indicate that developing brain may be differentially sensitive to environmental stimulation models. Specifically, our results show that hippocampal expression and distribution of parvalbumin in developing rats may be more influenced by exercise than by enriched environment. The mechanisms are not yet known. (AU)

• Processo FAPESP: 09/06953-4 - Estudo da plasticidade cerebral induzida pelo exercício físico
• Beneficiário: Ricardo Mario Arida
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/00035-1 - Reserva neural induzida pela prática de atividade física na adolescência: um estudo do fator neurotrófico derivado do encéfalo (BDNF), de seus receptores (TrkB e P75ntr) e vias de sinalização intracelular
• Beneficiário: Sérgio Gomes da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular