Enriched environment and exercise effects on parvalbumin expression and distribution in the hippocampal formation of developing rats

Author(s)

Serra, Fernando Tadeu ^{[1, 2, 3]} ; Silva Araujo, Bruno Henrique ^[4] ; Diaz Placencia, Eduardo Varejao ^[5] ; Henrique, Jessica Salles ^[1] ; Dona, Flavia ^[6] ; Torres, Laila Brito ^[7] ; da Silva Fernandes, Maria Jose ^[1] ; Arida, Ricardo Mario ^[1] ; da Silva, Swrgio Gomes ^{[2, 8, 3, 9]}

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Sao Paulo, SP - Brazil

^[2] Univ Mogi das Cruzes UMC, Mogi Das Cruzes, SP - Brazil

^[3] Fac Clube Naut Mogiano FCNM, Mogi Das Cruzes, SP - Brazil

^[4] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, BR-13083970 Campinas, SP - Brazil

^[5] Hosp Israelita Albert Einstein HIAE, Sao Paulo, SP - Brazil

^[6] Univ Anhanguera Sao Paulo UNIAN, Sao Paulo, SP - Brazil

^[7] Univ Sao Paulo, Human Genome & Stem Cell Res Ctr, Biosci Inst, Dept Genet & Evolutionary Biol, Sao Paulo, SP - Brazil

^[8] Ctr Univ UNIFAMINAS, Muriae, MG - Brazil

^[9] Fundacao Cristiano Varella FCV, Hosp Canc Muriae, Muriae, MG - Brazil

• Document type: Journal article
• Source: Brain Research Bulletin; v. 160, p. 85-90, JUL 2020.
• Web of Science Citations: 0

Abstract

Several models of environmental enrichment and physical exercise have been used to explore the experience effects on brain functions and plasticity, mainly in adult animals. In order to examine the early influence of these stimuli on developing brain, the present study used calcium-binding protein parvalbumin as neuroplastic marker in the hippocampal formation of male Wistar rats subjected to environmental enrichment or physical exercise from postnatal days 21 to 60 (P21-P60). In our study, no significant difference in hippocampal expression and distribution of parvalbumin was found between enriched and control rats. However, a significant increase in parvalbumin protein expression as well as in the number of neurons stained with parvalbumin was observed in the hippocampal formation of rats submitted to daily treadmill exercise when compared to the control rats. The hippocampal region with the highest number of parvalbumin neurons in exercised rats was Cornus of Amon 2 e 3 (CA2/CA3). These findings indicate that developing brain may be differentially sensitive to environmental stimulation models. Specifically, our results show that hippocampal expression and distribution of parvalbumin in developing rats may be more influenced by exercise than by enriched environment. The mechanisms are not yet known. (AU)

• FAPESP's process: 09/06953-4 - Brain plasticity induced by physical exercise
• Grantee: Ricardo Mario Arida
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/00035-1 - Neural reserve induced by practice of physical activity in adolescence: a study of the brain-derived neurotrophic factor (BDNF), its receptors (TrkB e p75ntr) and intracellular signaling pathways
• Grantee: Sérgio Gomes da Silva
• Support Opportunities: Regular Research Grants