Association of taste receptor gene polymorphisms with dental caries

Autor(es):Mostrar menos -

Juliana ARID ^[1] ; Lívia Azeredo Alves ANTUNES ^[2] ; Luiza Foltran de Azevedo KOCH ^[3] ; Silvane Silva EVANGELISTA ^[4] ; Katia Regina Felizardo VASCONCELOS ^[5] ; João Armando BRANCHER ^[6] ; Marilisa Carneiro Leão GABARDO ^[7] ; Ana Julia MILANI ^[8] ; André Luiz Tannus DUTRA ^[9] ; Leonardo Santos ANTUNES ^[10] ; Alexandre Rezende VIEIRA ^[11] ; Juliana FELTRIN-SOUZA ^[12] ; Erika Calvano KÜCHLER ^[13]

Afiliação do(s) autor(es):Mostrar menos -

^[1] Universidade de São Paulo. Ribeirão Preto Dental School. Department of Pediatric Dentistry - Brasil

^[2] Universidade Federal Fluminense. School of Dentistry. Department of Specific Formation - Brasil

^[3] Universidade Positivo. School of Health Sciences - Brasil

^[4] Universidade Paulista. Department of Pediatric Dentistry - Brasil

^[5] Universidade Federal do Amazonas. Amazonas Dental School. Department of Pediatric Dentistry - Brasil

^[6] Universidade Positivo. School of Health Sciences - Brasil

^[7] Universidade Positivo. School of Health Sciences - Brasil

^[8] Universidade Federal Fluminense. School of Dentistry - Brasil

^[9] Universidade Estadual do Amazonas - Brasil

^[10] Universidade Federal Fluminense. School of Dentistry. Department of Specific Formation - Brasil

^[11] University of Pittsburgh. Department of Oral Biology - Estados Unidos

^[12] Universidade Federal do Paraná. Department of Stomatology - Brasil

^[13] Universidade de São Paulo. Ribeirão Preto Dental School. Department of Pediatric Dentistry - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Oral Research; v. 34, 2020-06-19.

Resumo

Abstract This study was performed to evaluate the interplay between dental caries, nutritional status, and genetic polymorphisms in TAS1R1 and TAS1R2 (taste receptor, type 1, member 1 and 2) in preschool children and pre-adolescents. We included 525 subjects (306 preschool children and 219 pre-adolescents). Parents/caregivers answered a self-administered questionnaire about their children’s systemic health, characteristics, oral hygiene habits, and diet. Clinical examination was performed to evaluate dental caries and nutritional status. Saliva samples were collected for DNA extraction. The genotyping of rs17492553 ( TAS1R1 ), rs3935570, and rs4920566 ( TAS1R2 ) polymorphisms was performed using real-time PCR with Taqman Genotyping Master Mix and SNP assay. Both univariate and multivariate Poisson regression analyses with robust variance were used for the data analysis. In preschool children, consumption of sweets between meals increased the prevalence of dental caries by 85% (PR c = 1.85; 95%CI 1.39–2.46; p < 0.001), whereas in pre-adolescents, this prevalence increased by 34% (PR a = 1.34; 95%CI 1.11–1.62; p = 0.002), regardless of genetic polymorphisms . Moreover, individuals carrying at least one allele C in rs17492553 presented 23% more prevalence of dental caries (PR a = 1.23; 95%CI 1.02–1.49 p = 0.030). Nutritional status was not associated with dental caries, neither with genetic polymorphisms . Consumption of sweets between meals increased the prevalence of dental caries. In pre-adolescents, rs17492553 genetic polymorphism in TAS1R1 was associated with dental caries. (AU)

• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores