Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis

Autor(es)

Quirino, Thatyane de Castro ^[1] ; Ortolan, Luana dos Santos ^{[2, 3]} ; Sercundes, Michelle Klein ^{[1, 4]} ; Farias Marinho, Claudio Romero ^[5] ; Turato, Walter Miguel ^{[1, 6, 4]} ; Epiphanio, Sabrina ^{[1, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo - Brazil

^[3] Seattle Childrens Res Inst, Seattle, WA - USA

^[4] Ortolan, Luana dos Santos, Seattle Childrens Res Inst, Seattle, WA USA.Quirino, Thatyane de Castro, Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Sao Paulo - Brazil

^[6] Inst Pesquisas Energet & Nucl, Ctr Radiofarmacia, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 15, n. 5 MAY 29 2020.
• Citações Web of Science: 0

Resumo

Malaria-associated acute respiratory distress syndrome (ARDS) is an inflammatory disease causing alveolar-pulmonary barrier lesion and increased vascular permeability characterized by severe hypoxemia. Computed tomography (CT), among other imaging techniques, allows the morphological and quantitative identification of lung lesions during ARDS. This study aims to identify the onset of malaria-associated ARDS development in an experimental model by imaging diagnosis. Our results demonstrated that ARDS-developing mice presented decreased gaseous exchange and pulmonary insufficiency, as shown by the SPECT/CT technique. The pulmonary aeration disturbance in ARDS-developing mice on the 5th day post infection was characterized by aerated tissues decrease and nonaerated tissue accumulation, demonstrating increased vascular permeability and pleural effusion. The SPECT/CT technique allowed the early diagnosis in the experimental model, as well as the identification of the pulmonary aeration. Notwithstanding, despite the fact that this study contributes to better understand lung lesions during malaria-associated ARDS, further imaging studies are needed. (AU)

• Processo FAPESP: 13/20718-3 - O papel da citoadesão e dos receptores do tipo Toll (TLRs) na imunopatogênese da síndrome do desconforto respiratório agudo murino associado à malária grave
• Beneficiário: Luana dos Santos Ortolan
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/05782-8 - Estudo da permeabilidade vascular na síndrome do desconforto respiratório agudo associada à malária
• Beneficiário: Sabrina Epiphanio
• Modalidade de apoio: Auxílio à Pesquisa - Regular