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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis

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Author(s):
Quirino, Thatyane de Castro [1] ; Ortolan, Luana dos Santos [2, 3] ; Sercundes, Michelle Klein [1, 4] ; Farias Marinho, Claudio Romero [5] ; Turato, Walter Miguel [1, 6, 4] ; Epiphanio, Sabrina [1, 4]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo - Brazil
[3] Seattle Childrens Res Inst, Seattle, WA - USA
[4] Ortolan, Luana dos Santos, Seattle Childrens Res Inst, Seattle, WA USA.Quirino, Thatyane de Castro, Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Sao Paulo - Brazil
[6] Inst Pesquisas Energet & Nucl, Ctr Radiofarmacia, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: PLoS One; v. 15, n. 5 MAY 29 2020.
Web of Science Citations: 0
Abstract

Malaria-associated acute respiratory distress syndrome (ARDS) is an inflammatory disease causing alveolar-pulmonary barrier lesion and increased vascular permeability characterized by severe hypoxemia. Computed tomography (CT), among other imaging techniques, allows the morphological and quantitative identification of lung lesions during ARDS. This study aims to identify the onset of malaria-associated ARDS development in an experimental model by imaging diagnosis. Our results demonstrated that ARDS-developing mice presented decreased gaseous exchange and pulmonary insufficiency, as shown by the SPECT/CT technique. The pulmonary aeration disturbance in ARDS-developing mice on the 5th day post infection was characterized by aerated tissues decrease and nonaerated tissue accumulation, demonstrating increased vascular permeability and pleural effusion. The SPECT/CT technique allowed the early diagnosis in the experimental model, as well as the identification of the pulmonary aeration. Notwithstanding, despite the fact that this study contributes to better understand lung lesions during malaria-associated ARDS, further imaging studies are needed. (AU)

FAPESP's process: 13/20718-3 - The role of cytoadherence and Toll-like receptors (TLRs) in the immunopathogenesis of murine severe malaria associated acute respiratory distress syndrome
Grantee:Luana dos Santos Ortolan
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/05782-8 - The study of vascular permeability in the malaria-associated acute respiratory distress syndrome
Grantee:Sabrina Epiphanio
Support type: Regular Research Grants