Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity

Autor(es)

Oliveira, Rodrigo L. M. S. ^[1] ; Barbosa, Lucas ^{[1, 2]} ; Hurtado, Carolina R. ^{[3, 4]} ; Ramos, Lucas de P. ^[5] ; Montanheiro, Thais L. A. ^[6] ; Oliveira, Luciane D. ^[5] ; Tada, Dayane B. ^[4] ; Triches, Eliandra de Sousa ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] UNIFESP, Bioceram Lab, Sci & Technol Inst, Sao Jose Dos Campos, SP - Brazil

^[2] Montanheiro, Thais L. A., ITA, Plasmas \& Proc Lab, Sao Jose Dos Campos, SP, Brazil.Oliveira, Rodrigo L. M. S., UNIFESP, Bioceram Lab, Sci & Technol Inst, Sao Jose Dos Campos, SP - Brazil

^[3] IFSP, Sao Jose Dos Campos, SP - Brazil

^[4] UNIFESP, Nanomat & Nanotoxicol Lab, Sci & Technol Inst, Sao Jose Dos Campos, SP - Brazil

^[5] UNESP, Sci & Technol Inst, Sao Jose Dos Campos, SP - Brazil

^[6] ITA, Plasmas & Proc Lab, Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Biomedical Materials Research Part A; v. 108, n. 12 JUN 2020.
• Citações Web of Science: 1

Resumo

Over the past few years, several tridimensional synthetic bone grafts, known as scaffolds, are being developed to overcome the autologous grafts limitations. Among the materials used on the production of scaffolds, the 45S5 bioglass stands out due to its capacity of bonding to hard and soft tissues. Silver nanoparticles are well-known for their antimicrobial properties and their incorporation on the scaffold may promote its antimicrobial response, avoiding microorganism proliferation on the materials surface. This study proposes a simple way to coat 45S5 bioglass-based scaffolds with silver nanoparticles. The scaffolds were obtained by the sponge replication technique and the silver nanoparticles were incorporated by soaking under ultrasonic stirring. The antimicrobial activity of the scaffolds was analyzed against three different microbial strains:S. aureus,P. aeruginosa, andC. albicans. Due to the heat treatment during the scaffold production, the bioglass crystalized mainly in a sodium calcium silicate phase, forming a glass-ceramic scaffold. The silver nanoparticles were coated in a well-distributed manner throughout the scaffold, while avoiding their aggregation. The coated scaffold inhibited the growth of all the analyzed microorganism. Therefore, the use of ultrasonic stirring to coat the bioglass scaffold with silver nanoparticles showed to be an efficient way to promote its antimicrobial response. (AU)

• Processo FAPESP: 15/24659-7 - Síntese, caracterização e avaliação de biocompatibilidade de scaffolds bioceramicos preparados pelo método de freeze casting
• Beneficiário: Eliandra de Sousa Trichês
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/01697-6 - Síntese e funcionalização de nanopartículas bimetálicas para aplicação na terapia fotodinâmica de câncer
• Beneficiário: Dayane Batista Tada
• Modalidade de apoio: Auxílio à Pesquisa - Regular